A new pandemic

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   https://www.thailandmedical.news/news/another-worrisome-bird-flu-strain-h5n9-bird-flu-debuts-in-united-states or https://www.thailandmedical.news/news/another-worrisome-bird-flu-strain-h5n9-bird-flu-debuts-in-united-states 
https://afludiary.blogspot.com/2025/01/woah-california-reports-new-h5n9.html or https://afludiary.blogspot.com/2025/01/woah-california-reports-new-h5n9.html 

https://pmc.ncbi.nlm.nih.gov/articles/PMC4524050/ or https://pmc.ncbi.nlm.nih.gov/articles/PMC4524050/ ;

ABSTRACT
The novel H7N9 avian influenza virus (AIV) was demonstrated to cause severe human respiratory infections in China. Here, we examined poultry specimens from live bird markets linked to human H7N9 infection in Hangzhou, China. Metagenomic sequencing revealed mixed subtypes (H5, H7, H9, N1, N2, and N9). Subsequently, AIV subtypes H5N9, H7N9, and H9N2 were isolated. Evolutionary analysis showed that the hemagglutinin gene of the novel H5N9 virus originated from A/Muscovy duck/Vietnam/LBM227/2012 (H5N1), which belongs to clade 2.3.2.1. The neuraminidase gene of the novel H5N9 virus originated from human-infective A/Hangzhou/1/2013 (H7N9). The six internal genes were similar to those of other H5N1, H7N9, and H9N2 virus strains. The virus harbored the PQRERRRKR/GL motif characteristic of highly pathogenic AIVs at the HA cleavage site. Receptor-binding experiments demonstrated that the virus binds α-2,3 sialic acid but not α-2,6 sialic acid. Identically, pathogenicity experiments also showed that the virus caused low mortality rates in mice. This newly isolated H5N9 virus is a highly pathogenic reassortant virus originating from H5N1, H7N9, and H9N2 subtypes. Live bird markets represent a potential transmission risk to public health and the poultry industry.

DJ, US H5N9 may be a recombination of H5N1, H7N9 and H9N2. 

H7N9 is a know flu-risk in humans https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H7N9 or https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H7N9 so with also H5N1 risks for more cases/spread grow...

Rick Bright reposted
Chef José Andrés 
@chefjoseandres
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Today talking to farmers, they used to pay $3.50 per chicken and now is like $15 and actually they don’t get all the chickens they request…so the price of eggs and chicken is going up big time….milk too….the bird flu is real and will get worse if we don’t take it seriously…eggs will reach 1$ per egg..
-
Dr. Angela Rasmussen
@angie_rasmussen
·
2h
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When infectious diseases are ignored or neglected—as H5N1 has been—the consequences extend far beyond public health. They can cause severe economic disruption and food insecurity/shortages.

DJ, With also climate collapse decreasing food production "we are going in the wrong direction"...

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Dutch Josh 2 Members Profile Send Private Message Find Members Posts Add to Buddy List Admin Group Joined: 21 Aug 2024 Status: Offline Points: 1200	Post Options Post Reply Quote Dutch Josh 2 Report Post Thanks(0) Quote Reply Posted: 5 hours 48 minutes ago at 7:59am
	https://www.thailandmedical.news/news/another-worrisome-bird-flu-strain-h5n9-bird-flu-debuts-in-united-states or https://www.thailandmedical.news/news/another-worrisome-bird-flu-strain-h5n9-bird-flu-debuts-in-united-states https://afludiary.blogspot.com/2025/01/woah-california-reports-new-h5n9.html or https://afludiary.blogspot.com/2025/01/woah-california-reports-new-h5n9.html https://pmc.ncbi.nlm.nih.gov/articles/PMC4524050/ or https://pmc.ncbi.nlm.nih.gov/articles/PMC4524050/ ; ABSTRACT The novel H7N9 avian influenza virus (AIV) was demonstrated to cause severe human respiratory infections in China. Here, we examined poultry specimens from live bird markets linked to human H7N9 infection in Hangzhou, China. Metagenomic sequencing revealed mixed subtypes (H5, H7, H9, N1, N2, and N9). Subsequently, AIV subtypes H5N9, H7N9, and H9N2 were isolated. Evolutionary analysis showed that the hemagglutinin gene of the novel H5N9 virus originated from A/Muscovy duck/Vietnam/LBM227/2012 (H5N1), which belongs to clade 2.3.2.1. The neuraminidase gene of the novel H5N9 virus originated from human-infective A/Hangzhou/1/2013 (H7N9). The six internal genes were similar to those of other H5N1, H7N9, and H9N2 virus strains. The virus harbored the PQRERRRKR/GL motif characteristic of highly pathogenic AIVs at the HA cleavage site. Receptor-binding experiments demonstrated that the virus binds α-2,3 sialic acid but not α-2,6 sialic acid. Identically, pathogenicity experiments also showed that the virus caused low mortality rates in mice. This newly isolated H5N9 virus is a highly pathogenic reassortant virus originating from H5N1, H7N9, and H9N2 subtypes. Live bird markets represent a potential transmission risk to public health and the poultry industry. DJ, US H5N9 may be a recombination of H5N1, H7N9 and H9N2. H7N9 is a know flu-risk in humans https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H7N9 or https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H7N9 so with also H5N1 risks for more cases/spread grow... Rick Bright reposted Chef José Andrés @chefjoseandres < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Today talking to farmers, they used to pay $3.50 per chicken and now is like $15 and actually they don’t get all the chickens they request…so the price of eggs and chicken is going up big time….milk too….the bird flu is real and will get worse if we don’t take it seriously…eggs will reach 1$ per egg.. - Dr. Angela Rasmussen @angie_rasmussen · 2h < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> When infectious diseases are ignored or neglected—as H5N1 has been—the consequences extend far beyond public health. They can cause severe economic disruption and food insecurity/shortages. DJ, With also climate collapse decreasing food production "we are going in the wrong direction"...

Dutch Josh 2 Members Profile Send Private Message Find Members Posts Add to Buddy List Admin Group Joined: 21 Aug 2024 Status: Offline Points: 1200	Post Options Post Reply Quote Dutch Josh 2 Report Post Thanks(0) Quote Reply Posted: 5 hours 42 minutes ago at 8:05am
	https://www.wormsandgermsblog.com/2025/01/articles/animals/cats/pcr-testing-for-h5n1-influenza-in-dogs-and-cats/ or https://www.wormsandgermsblog.com/2025/01/articles/animals/cats/pcr-testing-for-h5n1-influenza-in-dogs-and-cats/ ; As H5N1 avian influenza continues to spread in wild birds and spills over into domestic birds and mammals of many kinds, we’re becoming more aware of the risks to domestic mammals and there are more questions about test selection and interpretation. Fortunately, testing for H5N1 influenza is relatively straightforward. For cats and dogs, the recommended samples for testing are typically oropharyngeal swabs, plus or minus nasal swabs (plus or minus other tissue samples of the animal is deceased. What tests are currently being run by veterinary diagnostic labs? PCR is the most accessible and useful test; diagnostic labs basically offer two types of influenza PCR: matrix / pan-influenza A PCR, and strain-specific PCRs (see below). Different commercial labs offer different tests or combinations of these tests, and the tests offered may also vary by species (i.e. what’s routinely done for dogs can be different from cats). Test offerings may also change over time as labs adapt to the ever-changing situation with flu in different populations. If influenza is a consideration in your patient, check with your lab regarding which tests they will run (particularly if you are submitting samples for a respiratory PCR panel) and how to interpret the results, including whether or not the test will detect H5N1 flu if that’s a concern. - Take home message Talk to your lab to know what they can (and can’t) do in terms of testing for H5N1 flu, and follow up testing. We can’t just stop at “flu positive.” Any such result needs to be scrutinized to make sure we know the strain (or strains) involved. DJ, Worldwide more testing/sequencing would be welcomed...Both CoViD and "flu" (H5N1, H5N5, H5N6, H5N8, H5N9...) do spread in MANY species...May jump from one species to another...