PANDEMIC ALERT LEVEL
123456
Forum Home Forum Home > Mpox Discussion Forum: > General Discussion
  New Posts New Posts RSS Feed - CoViD in the 1980's ????
  FAQ FAQ  Forum Search   Events   Register Register  Login Login

Mpox Discussion Forum: Latest News & Information Regarding the Clade 1b Mpox Virus

CoViD in the 1980's ????

 Post Reply Post Reply
Author
Message
Dutch Josh 2 View Drop Down
Admin Group
Admin Group


Joined: 21 Aug 2024
Status: Offline
Points: 899
Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Topic: CoViD in the 1980's ????
    Posted: 20 Sep 2024 at 11:30pm
https://www.ncf-net.org/what-is-cfids  or https://www.ncf-net.org/what-is-cfids ;

Chronic Fatigue Immune Dysfunction (CFIDS) is also known as Chronic Fatigue Syndrome (CFS) and Myalgic Encephalomyelitis (ME).

CFIDS is a disabling condition often affecting the central nervous system, brain, blood, muscles, joints, GI tract and lymph system. Symptoms include disabling fatigue which is not significantly helped by rest, orthostatic intolerance (inability to stand for periods of time), muscle weakness and pain, joint pain, sleep disturbances and un-refreshing sleep, cognitive problems including memory loss and difficulty concentrating, gastro-intestinal problems, headache, fevers and swollen lymph nodes.

The goal of the National CFIDS Foundation is to fund science to prove the cause along with a treatment or cure. A portion of all membership dues goes toward this along with all donations with no percentage held back. Although we feel we are close, we will continue to follow up on any leads until our goal is fully met.

Important research has already been funded by our all volunteer charity that found a slow decimation of a part of the immune system called Stat-1 which can only be caused by a limited number of viruses and bacteria. Our funding also found the reason why patients had dramatically adverse effects from anesthesia and how to prevent that as well as scientific proof that CFIDS/ME is an autoimmune disease. Our work will continue until the cause has been proven. At that time, we will, gratefully, be able to "go out of existence."

What's in a Name?

The illness currently called Chronic Fatigue Immune Dysfunction (CFIDS) or Chronic Fatigue Syndrome (CFS) is poorly defined, misunderstood, and controversial while remaining under-funded and under-researched. 

The names CFIDS and CFS trivialize the illness and subject patients to incredulity and ridicule. The CFS label not only fails to help those with ME, it harms them because treatments considered effective for CFS can make ME patients worse. Simply “renaming” CFS will not solve this problem.

Read and sign the petition we co-sponsor to try to have the United States government recognize the name and case definition of the internationally recognized neurological disease, Myalgic Encephalomyelitis (ME).*

DJ, Lots of infectious diseases may see long term health issues...Long CoViD has immunity issues/damage...but it is NOT NEW !!!
Back to Top
Dutch Josh 2 View Drop Down
Admin Group
Admin Group


Joined: 21 Aug 2024
Status: Offline
Points: 899
Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 20 Sep 2024 at 11:36pm
https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome or https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome ;

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling chronic illness. People with ME/CFS experience profound fatigue that does not go away with rest, sleep issues, and problems with memory or concentration. Further common symptoms include dizzinessnausea and pain.[3] The hallmark symptom is a worsening of the illness which starts hours to days after minor physical or mental activity. This "crash" can last from hours or days to several months.[10]

The cause of the disease is unknown.[11] ME/CFS often starts after an infection, such as mononucleosis.[12] It can run in families, but no genes that contribute to ME/CFS have been confirmed.[13] ME/CFS is associated with changes in the nervous and immune systems, as well as in energy production.[14] Diagnosis is based on symptoms because no diagnostic test is available.[7]

https://en.wikipedia.org/wiki/History_of_ME/CFS  or https://en.wikipedia.org/wiki/History_of_ME/CFS ;

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has a long history with an evolution in medical understanding, diagnoses and social perceptions.

In the early 19th century, the diagnosis of neuresthenia was popular, which had overlaps with current ME/CFS criteria. Various outbreaks of enigmatic disease occurred in the early 20th century, variably known as atypical poliomyelitisAkureyri disease or epidemic neuromyasthenia.

After an outbreak in the Royal Free Hospital in London, the disease became known as benign myalgic encephalomyelitis. Controversy erupted when psychiatrists who had not spoken to any of the patients called the outbreak a case of "mass hysteria". The first case definition of ME was published in 1986, and the first definition of CFS in 1988.

DJ, If "science" is unable to detect (any longer) a cause for disease-or clear "problems" they tend to go for claiming it is a mental issue...Untill also lots of medical workers catch it...
Back to Top
Dutch Josh 2 View Drop Down
Admin Group
Admin Group


Joined: 21 Aug 2024
Status: Offline
Points: 899
Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 20 Sep 2024 at 11:44pm
DJ-There have been "reports" of ME-CFS for over 200 years...describing symptoms but hardly any science involved...

https://en.wikipedia.org/wiki/History_of_ME/CFS#Case_definitions_(1986_onwards) or https://en.wikipedia.org/wiki/History_of_ME/CFS#Case_definitions_(1986_onwards) ;

The illness gained national attention in the United States when the popular magazine Hippocrates ran a cover story of an epidemic at Lake TahoeNevada, in the mid-1980s.[34] The designation Chronic Epstein–Barr Virus was in use in the U.S.,[35][36] but the magazine used the term "Raggedy Ann Syndrome" to note the fatigue and loss of muscle power patients felt.[37] Researchers investigating the Lake Tahoe cluster did not find evidence that EBV was involved, and they proposed the name "chronic fatigue syndrome", describing a main symptom of the illness.[38][39] They published the first working case definition for CFS in 1988.[40] Research increased considerably, and more so after the criteria were relaxed in 1994.[41]

In 1990, researchers presented evidence they found DNA sequences very similar to the human HTLV-II retrovirus in some CFS patients, at a conference in Kyoto, Japan.[42][43] Their study was later published in the Proceedings of the National Academy of Sciences.[44] A reporter on Prime Time Live stated the announcement made headlines all over the world. The CDC first ignored their findings,[45] then later conducted a study and published a paper that refuted the hypothesis.[46]

In the United Kingdom, the Chief Medical Officer Kenneth Calman requested a report from the medical Royal Colleges in 1996. This led to the publication of a joint report in which the term "chronic fatigue syndrome" was found to be most representative.[47] This was followed in 2002 by a further report by the new CMO, Liam Donaldson.[48]

The U.S. Centers for Disease Control & Prevention (CDC) recognize CFS as a serious illness, and launched a campaign in June 2006 to raise public and medical awareness about it.[49][50]


DJ, the "bad news" then and now is "economy first"...so a lot of people with CFS-ME or Long CoViD end up in poverty...Often also "medical workers" claiming it is a mental issue...

Depression ON TOP of CFS-ME may be a normal reaction to a lack of (willingness to) understand/investigate...

Another aspect is "ununderstandable diseases" https://en.wikipedia.org/wiki/Functional_somatic_syndrome  or https://en.wikipedia.org/wiki/Functional_somatic_syndrome do remind people/society of how vulnerable they are...
Back to Top
Dutch Josh 2 View Drop Down
Admin Group
Admin Group


Joined: 21 Aug 2024
Status: Offline
Points: 899
Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 22 Sep 2024 at 1:29am
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full  or https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full 
Front. Med., 02 June 2023

ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature
Some patients remain unwell for months after “recovering” from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms that greatly interfere with their ability to function and that can leave some people housebound and disabled. 

The illness (Long COVID) is similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well as to persisting illnesses that can follow a wide variety of other infectious agents and following major traumatic injury. Together, these illnesses are projected to cost the U.S. trillions of dollars. 

In this review, we first compare the symptoms of ME/CFS and Long COVID, noting the considerable similarities and the few differences. 

We then compare in extensive detail the underlying pathophysiology of these two conditions, focusing on abnormalities of the central and autonomic nervous system, lungs, heart, vasculature, immune system, gut microbiome, energy metabolism and redox balance. This comparison highlights how strong the evidence is for each abnormality, in each illness, and helps to set priorities for future investigation. 

The review provides a current road map to the extensive literature on the underlying biology of both illnesses.

DJ, Health stories SHOULD be about avoiding/limiting suffering...however in the present brutal reality "costs matter more than humans"...

In this review, we compare the symptoms of Long COVID and ME/CFS, noting considerable similarities and some differences. Early in the study of both illnesses, the lack of objective biomarkers led some to question whether the illnesses were “real”—whether people might be imagining or even fabricating their symptoms.

In this review we summarize the emerging evidence that, in fact, there are many underlying biological abnormalities reported in both illnesses, documented by multiple laboratories. Moreover, we show that the two illnesses share many of these underlying abnormalities, just as they share many symptoms. That is, both illnesses are “real,” and both share similar biological abnormalities.

Understanding the underlying biology of these illnesses is critically important, given the burden they are placing on all societies. The National Academy of Medicine and Centers for Disease Control and Prevention (CDC) estimate that, in the U.S., ME/CFS affects up to 2.5 million people and generates direct and indirect expenses of approximately $17–24 billion annually (1). It also has been reported in many countries around the world.

-
Myalgic encephalomyelitis/CFS often, but not always, follows in the wake of an apparent “infectious-like” illness characterized by respiratory and gastrointestinal symptoms, fatigue, myalgias and other symptoms as well as fever and lymphadenopathy (518). This “infectious-like” illness often is little different, initially, from the common, transient infectious illnesses that most people experience throughout life. It is not standard medical practice to test for the responsible infectious agent in people with common and transient infectious illnesses. Thus, typically no testing has been done to determine the cause of the initial “infectious-like” illness that then becomes a chronic illness in subsequent months and years.
DJ, ME-CFS (etc) does not go away...lots of people suffer from it for decades...From that perspective realism may give Long CoViD patients an idea of what to expect. 

"Graded excercise" etc. can help to "optimize capabilities"....full recovery however is not very likely. This realism may be hard to swallow-however it should be used to provide lots of L.C. patients both (mental) support and an income...
Back to Top
Dutch Josh 2 View Drop Down
Admin Group
Admin Group


Joined: 21 Aug 2024
Status: Offline
Points: 899
Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 22 Sep 2024 at 1:52am
part 2 (https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full  or https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full )

Attempts to identify a single and possibly novel infectious agent as the cause of most cases of ME/CFS have been unsuccessful. For example, claims that murine leukemia viruses cause ME/CFS have been refuted (528529), as have similar claims for Borna disease virus (530).
DJ-

https://en.wikipedia.org/wiki/Common_cold  or https://en.wikipedia.org/wiki/Common_cold ;

The common cold or the cold is a viral infectious disease of the upper respiratory tract that primarily affects the respiratory mucosa of the nosethroatsinuses, and larynx.[6][8] Signs and symptoms may appear in as little as two days after exposure to the virus.[6] These may include coughingsore throatrunny nosesneezingheadache, and fever.[3][4] People usually recover in seven to ten days,[3] but some symptoms may last up to three weeks.[7] Occasionally, those with other health problems may develop pneumonia.[3]

Well over 200 virus strains are implicated in causing the common cold, with rhinovirusescoronavirusesadenoviruses and enteroviruses being the most common.[14] 


Is it possible-even likely-given the present SARS-2/CoViD-19 resulting in "Long CoViD" that earlier some "corona-cold virusses" did play a role in the ME-CFS (etc) story ? 
Back to Top
Dutch Josh 2 View Drop Down
Admin Group
Admin Group


Joined: 21 Aug 2024
Status: Offline
Points: 899
Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 11 Oct 2024 at 8:33am
< aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;">
Researchers exposed skeletal muscle to serum from ppl w/ #MECFS or #LongCovid hrs : contractile profile severely compromised, shift to glycolysis @ 96-144 hrs: high fatiguability, fragile tissue, fragmented mitochondria #MedTwitter, PEM is real.

link; https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353  or https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353 ;
Prolonging the exposure to 96 and 144 hours induced high fatiguability, and fragility in tissues.

 The mitochondria, at longer exposures, appeared to be fragmented and assumed a toroidal conformation indicating a change in mitochondrial membrane potential. 

We hypothesize that the disease progresses through an intermediary stress-induced hypermetabolic state, ultimately leading to severe deterioration of muscle function. 

This is the first account of research that proposes acquired metabolic plasticity in 3D skeletal muscles exposed to ME/CFS and Long COVID-19 sera.

-DJ-The conclusion -my view- pushing people with ME-CFS/Long CoViD beyond their limits brings serious damage...
< aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;">
To be clear for anyone new to my posts, this study isn’t when I decided post-exertional malaise (PEM) is real. Many people w/ #MECFS & #LongCovid have described severe fatigue & said exertion worsens symptoms, sometimes dramatically. Listen to patients. Believe them. #MedTwitter

-
Back to Top
Dutch Josh 2 View Drop Down
Admin Group
Admin Group


Joined: 21 Aug 2024
Status: Offline
Points: 899
Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 12 Oct 2024 at 9:17am
https://www.thailandmedical.news/news/study-finds-that-long-covid-19-patients-exhibit-impaired-fat-oxidation  or https://www.thailandmedical.news/news/study-finds-that-long-covid-19-patients-exhibit-impaired-fat-oxidation 

link to https://www.sciencedirect.com/science/article/pii/S0261561424003686 or https://www.sciencedirect.com/science/article/pii/S0261561424003686 ;

Analysis of fat oxidation capacity during cardiopulmonary exercise testing indicates long-lasting metabolic disturbance in patients with Post-COVID-19 Syndrome


DJ, This study did find https://en.wikipedia.org/wiki/Mitochondrion or https://en.wikipedia.org/wiki/Mitochondrion did not function the way they should in Long CoViD cases...A fitting excercise plan did bring improvement...

It reminds me of the discussion also in ME-CFS cases; Do people "optimize" or recover ? 

It may be effective for some groups-age/gender linked...?
Back to Top
 Post Reply Post Reply

Forum Jump Forum Permissions View Drop Down

Forum Software by Web Wiz Forums® version 12.07
Copyright ©2001-2024 Web Wiz Ltd.

This page was generated in 0.062 seconds.