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Mpox Discussion Forum: Latest News & Information Regarding the Clade 1b Mpox Virus

A new pandemic

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Dutch Josh 2 View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 9 hours 54 minutes ago at 11:26pm
Some countries report now more people are dying from flu then from CoViD. DJ-A lot of people may die from both...

So after the present high flu numbers will CoViD numbers 9again) go up ? Will the flu-season end in march ? 

If H5, H7, H9 etc. types of flu are (better) in spreading between humans then flu cases may go up again...

Mpox cases are "slowly spreading", measles is another story...

Another "new development" is repoting/news did even get worse..."saving the economy" is a mistake being repeated over and over...

DJ-The outcome of this process may be -the "best" higher excess deaths (+5/10% above "pre-pandemic 2019").  Disease "X" scenario could see a new disease-with humans having no (longer) immunity spreading and killing very agressive...

Time will tell...even the best experts admit they are surprised often...The H5N1 "story" at present is unbelievable and should have been stopped much earlier (and in many places). 

H5N1 is now -like CoViD- widespread in many species/mammals and will be a growing risk. 
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 9 hours 30 minutes ago at 11:50pm
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24 states + DC in the CDC high/very high range. An estimated 1 in 87 people in the U.S. are actively infectious with COVlD today.
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Canada: 'Exceptionally rare' mutation on H5N1 virus tied to antiviral drug resistance "..discovery of a mutated H5N1 avian flu strain resistant to the antiviral drug oseltamivir on eight chicken farms in British Columbia in October 2024."

DJ, https://www.cidrap.umn.edu/avian-influenza-bird-flu/exceptionally-rare-mutation-h5n1-virus-canada-tied-antiviral-drug or https://www.cidrap.umn.edu/avian-influenza-bird-flu/exceptionally-rare-mutation-h5n1-virus-canada-tied-antiviral-drug ;

"Isolates from 8 farms reveal a mutation in the neuraminidase protein (H275Y) that is exceptionally rare among clade 2.3.4.4b viruses (present in 0.045% of publicly available clade 2.3.4.4b isolates)," the researchers wrote. "NA-H275Y is a well-known marker of resistance to the neuraminidase inhibitor oseltamivir."

The virus likely emerged in Canada in September 2024, the authors said. The US Department of Agriculture later updated its North American A(H5N1) genotyping tool GenoFlu to designate the virus as genotype D1.1. 

"Despite evidence to suggest this substitution reduces viral fitness, viruses harboring this substitution spread rapidly across 8 farms in the 15 days following its initial detection," the researchers wrote. "As oseltamivir is the most widely used therapeutic and prophylactic against IAV [influenza A virus], the continued circulation of viruses harboring NA-H275Y may necessitate a re-evaluation of influenza treatment strategies in Canada."

It's unclear whether the mutated virus is still circulating.

So...in september 2024 the mutated form started spreading in Canada...The mutation itself may limit spread, however the "immunity/anti-viral escape" may-in the long run-see the mutation helping the virus to "survive"...
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