PANDEMIC ALERT LEVEL |
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Mpox Discussion Forum: Latest News & Information Regarding the Clade 1b Mpox Virus |
A new pandemic |
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Dutch Josh 2 ![]() Admin Group ![]() Joined: 21 Aug 2024 Status: Offline Points: 1759 |
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After yesterday;
< aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Kenya: Herders worried as mysterious camel disease strikes Hurri Hills in Marsabit Now; < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> DJ, Bats can carry up to 30 different sorts of corona viruses...The Laos-China rain forest border region has a lot of bats...so "NO need for lab leak claims"! (DJ-I do not 100% rule out lab leaks for diseases but high security labs have low air pressure-so a leak would mean air from outside moving in...all kinds of alarms going off...Also-in general-a lot of work is done with weakened viruses that most likely would not survive outside. Military bio-weapon labs (in Africa, other countries with limited safety rules/supervision may be a different story...One would NOT expect such a lab near Wuhan-urban area population 20 million+...) So..."SARS-3" starting ? Or are we already seeing so many diversion in CoViD variants we are already in lots of SARS-corona viruses pandemics ??? (SARS=Severe Acute Respitory Syndrome...does NOT have to be (only) linked with a COrona VIral Disease/CoViD).
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Dutch Josh 2 ![]() Admin Group ![]() Joined: 21 Aug 2024 Status: Offline Points: 1759 |
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< aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> BREAKING: Bird Flu Virus Mutating Rapidly Scientists Warn Current Vaccines May Fall Short
H5N1 influenza is evolving rapidly, weakening the effectiveness of existing antibodies and increasing its potential threat to humans. DJ, Both CoViD and "bird flu" are GLOBAL problems in MANY species....and OUT of ANY control...H5N1 itself may have hundreds of different sub-types in over a hundred sort of mammals and birds...Lots of other H5, H7, H9, H10 risks... https://afludiary.blogspot.com/2025/03/ecdcefsa-quarterly-avian-influenza.html or https://afludiary.blogspot.com/2025/03/ecdcefsa-quarterly-avian-influenza.html ; The ECDC publishes a highly detailed avian influenza surveillance report roughly every 3 months, and while they tend to be EU centric, in its 70+ pages you'll find ample coverage of outbreaks and infections from around the world on a wide variety of avian subtypes.
These highly detailed quarterly reports make excellent reference material, well worth perusing. - Between 7 December 2024 and 7 March 2025, 743 highly pathogenic avian influenza (HPAI) A(H5) virus detections were reported in domestic (239) and wild (504) birds across 31 countries in Europe. HPAI A(H5N1) virus detections were predominant and mainly located in central, western and south-eastern Europe. No evidence of human-to-human transmission has been documented during the reporting period. The risk of infection with the avian A(H5) influenza viruses of clade 2.3.4.4b currently circulating in Europe remains low for the general public in the European Union/European Economic Area (EU/EEA). The risk of infection remains low-to-moderate for those occupationally or otherwise exposed to infected animals or contaminated environments. - In the United States of America (USA), the number of dairy cattle farms reportedly affected rose to almost 1,000 in 17 States, and a different HPAI A(H5N1) virus genotype (D1.1) was reported in this species. Between 12 December 2024 and 7 March 2025, 22 new cases of avian influenza virus infection in humans were reported in the USA (12 A(H5) cases), Cambodia (two A(H5N1) cases), United Kingdom (one A(H5N1) case), and China (six A(H9N2) cases and one A(H10N3) case). Most of the A(H5) human cases (93%, n = 14/15) had reported exposure to poultry or dairy cattle prior to avian influenza virus detection or onset of illness. Considering the widespread circulation of avian influenza viruses in animal populations, human infections with avian influenza viruses remain infrequent. - Last summer the ECDC published Enhanced Influenza Surveillance to Detect Avian Influenza Virus Infections in the EU/EEA During the Inter-Seasonal Period which cautioned:
Similarly, in 2023's analysis from the UKHSA (see TTD (Time to Detect): Revisited), the UK estimated there could be dozens or even hundreds of undetected human H5N1 infections before public health surveillance would likely detect them, potentially over a period of weeks or even months. - Beyond that, it is no secret that many countries (including our own) sometimes elect to only selectively release information on emerging disease threats. For reasons that likely vary widely between nations, details that once were shared are now often redacted or delayed (see From Here To Impunity). While the risk assessments provided in this overview (low or very low for the general public) seem reasonable based on the data provided, confidence in the quality and completeness of that data is difficult to gauge. Which is why - despite recent slowdowns in reported cases - we can't afford to be complacent. DJ, We very likely will NOT detect human spread of H5-etc in Africa untill it is "going wild"...We do not even want to know what (new) CoViD variants are doing (and in what species)... Bacterial, fungal (co)infection-risks are ignored... "Pseudo political"-childish-"blame games" are NOT a pandemic strategy...The only goal seems to be limiting economic damage... The present ongoing (lack of) strategy will worsen pandemic risks... And most of us-like with climate-do not seem to care...
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Dutch Josh 2 ![]() Admin Group ![]() Joined: 21 Aug 2024 Status: Offline Points: 1759 |
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https://www.zerohedge.com/energy/burgum-orders-nearly-20-million-acres-alaska-opened-oil-gas-development or https://www.zerohedge.com/energy/burgum-orders-nearly-20-million-acres-alaska-opened-oil-gas-development ;
Five weeks ago the UK made a brief announcement on the detection of HPAI H5N5 In 2 Grey Seals in Norfolk. This was the first detection of HPAI H5 in a non-avian species in the UK in nearly 2 years, and the first such detection involving the H5N5 subtype. Last November, the UK reported an outbreak in poultry of H5N5 in Yorkshire along with > 2 dozen dead birds infected with H5N5 from around the kingdom. - Last July, in Cell Reports: Multiple Transatlantic Incursions of HPAI clade 2.3.4.4b A(H5N5) Virus into North America and Spillover to Mammals, researchers reported finding the mammalian adaptive E627K mutation in a number of samples. They wrote:
Over the weekend the UK's APHA announced the detection of an additional 13 grey seals with H5N5, and the disclosure that the mammalian E627K mutation was detected as well. - While H5N5 remains a minor player, it is not impossible that we could a shift from H5N1 to H5N5, or H5N6 (or to some other n-type), in the months or years ahead. After all, little more than 5 years ago H5N1 was in serious decline, while HPAI H5N8 was dominant. The H5Nx virus has an large - and growing - array of diverse avian and mammalian hosts to inhabit, and no lack of genetic diversity on which to draw. While past performance is no guarantee of future results, its current trajectory is nevertheless concerning. - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> First case of bird flu in sheep found on UK farm https://www.bbc.com/news/articles/c3w1jj0jzl2o or https://www.bbc.com/news/articles/c3w1jj0jzl2o ; The world's first case of bird flu in sheep has been found in the UK, the nation's chief veterinary officer has confirmed. The exact location of the farm has not been revealed, but a government spokesperson said the case was identified on a site in Yorkshire where bird flu had been confirmed in captive birds. The spokesperson said the single infected sheep had been "humanely culled" and no further cases among the flock were found after "extensive testing". "There is no evidence to suggest an increased risk to the nation's livestock population," they added. DJ, Very likely lots of H5, H7, H9 variants may be spreading in (sea)mammals...certainly those that do catch/spread the virus without (much) symptoms may escape testing/detection... < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> ‘Moroccan measles variant’ found in Brussels sewage water DJ, quite a lot of imported Moroccan measles cases as well in NL...
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Dutch Josh 2 ![]() Admin Group ![]() Joined: 21 Aug 2024 Status: Offline Points: 1759 |
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https://nltimes.nl/2025/03/24/psv-confirms-player-stricken-tuberculosis-footballer-identified or https://nltimes.nl/2025/03/24/psv-confirms-player-stricken-tuberculosis-footballer-identified ; A player from PSV’s first team has been diagnosed with active tuberculosis, the club confirmed. The player, whose identity has not been disclosed, is receiving medical care and is in stable condition. While the risk of further infections is considered low, health authorities are said to be monitoring the situation closely. The case has been reported to the GGD Brabant-Zuidoost, the regional public health service, which has launched a source and contact investigation. PSV’s medical staff, the treating pulmonologist, and the GGD have reportedly implemented all necessary precautions following standard health protocols. As of now, there are no indications that individuals in close contact with the infected player have contracted the disease. DJ, PSV is a major NL footbal/soccer-club..."spread risks limited"... < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Monthly Forecast
Average percentage of the population infectious: 1.0% (1 in 96)
Average new daily infections: 496,567
Total new infections over the next month: 14,897,000
Estimated monthly Long COVID cases: 745,000 to 2,979,000 DJ, US CoViD numbers above based on a "model" https://pmc19.com/data/ or https://pmc19.com/data/ https://www.corona-lokaal.nl/locatie/Nederland/waterzuivering/Nederland or https://www.corona-lokaal.nl/locatie/Nederland/waterzuivering/Nederland CoViD in NL wastewater also increasing... https://www.thailandmedical.news/news/h5n1-bird-flu-virus-found-in-sheep-for-the-first-time-in-england-sparks-growing-concern or https://www.thailandmedical.news/news/h5n1-bird-flu-virus-found-in-sheep-for-the-first-time-in-england-sparks-growing-concern DJ-Birds in the area had the same H5N1 variant...so did the sheep eat contaminated grass ? Is the level of virus-parts/activity enough to cause disease ? (Or is there aerosol spread-strong enough to cause infection ???)
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Dutch Josh 2 ![]() Admin Group ![]() Joined: 21 Aug 2024 Status: Offline Points: 1759 |
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< aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> H5N1 has NEVER behaved like this.
- < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> #H5N1 #AvianInfluenza Clade 2.3.2.1c
Quick analysis of the sequence uploaded to from #Cambodia (from 3-year old boy from #Kratie)
PB2 mutations: N82S, E191G, I411V, F446L, P469L, E627K, A661T, V667I, A674T, M676I, G682S, A684S, N711S
Ref: A/Duck/Guangdong/E1/2012
1/n - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Note: PB2 E627K mammalian adaptation signature is present
This is not the H5N1 clade 2.3.4.4b #avianflu circulating in the USA - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> HA mutations: K3R, S12N, K31Q, T87I, V102A, S110N, T150A, N170D, R205K, R228K, I273V, V285A, K286Q, K339R, R388K, I390V, R461K, Q506R, M526I
Ref: A/Cambodia/NPH230032/2023(H5N1)
3/n - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> NA mutations: V34I, A46T, L60V, V79I, I129V, I191L, N250D, R293Q, R312T, N396D
Ref: A/Cambodia/NPH230032/2023(H5N1)
4/n Also ; https://www.wormsandgermsblog.com/2025/03/articles/uncategorized/h5n1-influenza-in-sheep/ or https://www.wormsandgermsblog.com/2025/03/articles/uncategorized/h5n1-influenza-in-sheep/ ; The Food Standards Agency advises that properly cooked poultry and poultry products, including eggs, remain safe to eat and avian influenza poses a very low food safety risk to UK consumers since the H5N1 virus is not normally transmitted through food.” Awareness. Diligence. Good use of routine practices. Continued surveillance. Those are the key factors for limiting the risk from this virus. DJ, The UK sheep was on a mixed farm with also infected poultry...it still does NOT explain how the sheep did get the virus (and symptoms-or only via testing of the sheep milk ?) It is impossible to test all possible infected mammals for all kinds of flu (H5N5 also in the UK, H7, H9...) Looking at how "politics" is worsening climate problems and wars I do not see ANY reason for optimism on "government action" to stop worsening public health...In fact defunding public health for more (NATO expansion/saving US$) wars seems to be the normal insanity...supported still by a lot of voters...
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Dutch Josh 2 ![]() Admin Group ![]() Joined: 21 Aug 2024 Status: Offline Points: 1759 |
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DJ, the "new pandemic" may be a multi-old-diseases mix...Those diseases interacting with eachother may be making it "very hard" to control-if there is any intention/means to control it...
< aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Measles case confirmed in DC with exposures on Amtrak DJ, of course vaccinations-in time- may limit measles....A global problem.. https://afludiary.blogspot.com/2025/03/usda-adds-11-more-domestic-cats-to-h5n1.html or https://afludiary.blogspot.com/2025/03/usda-adds-11-more-domestic-cats-to-h5n1.html ; USDA Adds 11 More Domestic Cats To H5N1 List (n=126)It's been 2 weeks since their last update, but this afternoon the USDA added 24 new entries to their Mammalian Wildlife with H5N1 list , including 11 domestic cats, 6 striped skunks, and 3 black bears. DJ,H5N1 and other types of ird flu" are widespread in mammals around the globe.. https://www.thailandmedical.news/news/alarming-rise-in-tuberculosis-cases-among-children-across-europe-and-central-asia or https://www.thailandmedical.news/news/alarming-rise-in-tuberculosis-cases-among-children-across-europe-and-central-asia DJ-Basic problem; Pandemic control is NOT top of any agenda..
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Dutch Josh 2 ![]() Admin Group ![]() Joined: 21 Aug 2024 Status: Offline Points: 1759 |
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DJ, There is a seperate item on measles in 2025 on latest news...NL, Vietnam, Morocco, Romania etc. also in high numbers...NL in the first three months of 2025 has already had more cases of measles then in all of 2024-wich in itself was also an active year...
TB also increasing in NL...like in many other places... H5 (etc) in cattle https://afludiary.blogspot.com/2025/03/virology-detection-of-antibodies.html or https://afludiary.blogspot.com/2025/03/virology-detection-of-antibodies.html ; Since then, HPAI H5 has turned up in hundreds of cattle herds, along with sporadic spillovers into goats, alpacas, pigs, and most recently a sheep in the UK. Quite frankly, the more we look, the more we find that H5 in livestock is more common than we knew. All of which brings us to a new study, published this week in Virology, which looks for IAV antibodies in United States cattle in the year prior to the discovery of H5N1 in dairy cows. And once again, we find that evidence of (non-H5) IAV infection was common across a wide sampling of serum samples taken in 2023 and early 2024.
DJ, all types of flu may spread more widely then humans... These findings indicate that co-infection with IAVs might occur in some individual cattle. Considering that the H5N1 HPAIV is circulating in dairy cattle herds (8) and cattle can be infected with human and swine IAVs, reassortment of IAVs from different species might happen in cattle (10), generating novel genotypes of H5Nx virus with pandemic potential or at least with increased ability for zoonotic transmission. DJ, "One Health" realizing often animal and human health issues do mix however is costly...Ignoring it may -at the end- cost more... While this new information should inspire a paradigm shift in the way we deal with IAV in livestock, we have a long history of denying potential health threats and of maintaining the status quo when facts are either inconvenient, expensive, or difficult to deal with. But at least with the help of this kind of research, we'll know why we failed. DJ, NL has over 100 million farm animals-most poultry...we have millions of pets...Realizing the health risks may result in decreasing meat consumption increase of meat/food prices...oat-milk may soon become the better option... We have to change the system-what we eat...But just like with climate changing habbits seems to be asking to much...Learning the hard way...
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Dutch Josh 2 ![]() Admin Group ![]() Joined: 21 Aug 2024 Status: Offline Points: 1759 |
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https://www.thailandmedical.news/news/new-sars-cov-2-bq-1-1-1-variant-with-40-spike-mutations-and-many-other-worrisome-genetic-changes-detected-in-canada or https://www.thailandmedical.news/news/new-sars-cov-2-bq-1-1-1-variant-with-40-spike-mutations-and-many-other-worrisome-genetic-changes-detected-in-canada
link to https://github.com/sars-cov-2-variants/lineage-proposals/issues/2511 or https://github.com/sars-cov-2-variants/lineage-proposals/issues/2511 ; BQ.1.1.1 >40 spike mutations saltation (1 Canada) #2511< -component="Icon" ="" ="prc---c50BI prc--Icon-szpyj" -loading="false" -no-visuals="true" -size="medium" -variant="in" aria-describedby=":r7:-loading-announcement" aria-labelledby=":r5:" style="font-style: inherit; font-variant: inherit; font-weight: var---text-weight-medium,500; font-stretch: inherit; font-size: var--text--size-medium,.875rem; line-height: inherit; font-family: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; margin: 0px; overflow: ; appearance: none; cursor: pointer; border-radius: var--borderRadius-medium,.375rem; align-items: center; border-color: rgba0, 0, 0, 0; display: inline-grid; gap: var---size-8,.5rem; height: var--control-medium-size,2rem; place-: center; min-width: unset; padding: unset; transition: color 80ms cubic-bezier0.65, 0, 0.35, 1, fill, , border-color; user-: none; flex-shrink: 0; width: var--control-medium-size,2rem; -shadow: none;"> DJ, A BQ.1.1.1 CoViD variant with (over) 40 mutations-likely from a host with immunity problems-was detected in Canada...Some of the mutations could bring increased immunity evasion... Even worse-unclear how many of these variants there may be because of lack of testing/sequencing... https://afludiary.blogspot.com/2025/03/cell-early-warning-signals-and-role-of.html or https://afludiary.blogspot.com/2025/03/cell-early-warning-signals-and-role-of.html ; While H9N2 may not be at the very top of our pandemic threats list, this LPAI virus is viewed by many as an important and influential player in the avian flu world.
But H9N2's biggest threat may come its ability to reassort with other, potentially more virulent, subtypes. - It seems likely that unless and until H9N2 can be better controlled, our avian flu woes may extend far beyond just H5Nx in the years ahead. ---- https://afludiary.blogspot.com/2025/03/nature-lengthy-delays-in-h5n1-genome.html or https://afludiary.blogspot.com/2025/03/nature-lengthy-delays-in-h5n1-genome.html ; While many countries have long held avian flu (and other emerging infectious disease) information close to the vest (a few examples from Indonesia, China, Egypt, and Saudi Arabia), in recent years it has increasingly become the norm, rather than the exception. WHO member nations are required under the 2005 IHR to report novel virus detections within 24-hours, but the reality is that many governments are often slow - or simply refuse - to release `bad news' which may impact their economy, or political stability (see From Here To Impunity). -
But at least our leaders can honestly say when that happens; they never saw it coming. DJ, CoViD is getting worse, all kinds of flu...worse...measles, TB, Mpox...
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Dutch Josh 2 ![]() Admin Group ![]() Joined: 21 Aug 2024 Status: Offline Points: 1759 |
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< aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> The U.S. has actively dismantled the global disease-detection programs we all—including Americans—rely on to stay safe
Today this administration’s short-sighted global health agenda got even even worse
It’s ending its support for vaccine programs around the world
Why?? - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Replying to "Viral genetic changes have enabled transmission of the highly pathogenic avian influenza #H5N1 to hundreds of species of birds and mammals leading to repeated animal-to-human transmission events, including 72 reported to the World Health Organization in 2024." - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Replying to "Real-time surveillance of viral genomes enables the detection of new variants, the assessment of their impact on infectivity and disease severity, the estimation of rates of spread and routes of transmission using new phylogenetic tools, and evidence-based decision making by public health authorities, but it DJ, There may be a 100+ variants of H5N1, very likely a million+ variants of CoViD, at least 4 clades of Mpox...measles, TB may also go for diversification... Vitamin overdose=vitamin poisening=stupid ! My-non expert- view; We are on route to "disease X" to wich we will have NO defense, with a high CFR/"kill ratio"...and we are not even looking ! Age of insanity-rule of idiots !
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Dutch Josh 2 ![]() Admin Group ![]() Joined: 21 Aug 2024 Status: Offline Points: 1759 |
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Another story/study on a pig coronavirus (earlier-2015 detected in Haiti) that may be able to develop into a SARS-3 risk...
https://www.thailandmedical.news/news/sars-cov-3-new-coronavirus-strain-from-pigs-shows-ability-to-alter-human-genes-and-raises-fears-of-zoonotic-threat or https://www.thailandmedical.news/news/sars-cov-3-new-coronavirus-strain-from-pigs-shows-ability-to-alter-human-genes-and-raises-fears-of-zoonotic-threat link to https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1534907/full or https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1534907/full ; Introduction: Porcine deltacoronavirus (PDCoV) is an enteropathogenic coronavirus that causes acute diarrhea, vomiting, dehydration, and even death in piglets, resulting in serious economic losses to the pork industry worldwide. PDCoV has received much attention owing to its broad host range, including humans, posing a potential threat to public health. However, the prevalence, characteristics, and host cellular gene expression of PDCoV remain poorly understood. - Porcine deltacoronavirus (PDCoV), also referred to as coronavirus HKU15, is a member of the genus Deltacoronavirus of the family Coronaviridae (Kikuti et al., 2024). PDCoV causes diarrhea, dehydration, vomiting, and enteric damage in neonatal piglets, similar to those caused by porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) (Bahoussi et al., 2022; Yin et al., 2022). PDCoV was first reported in pigs in Hong Kong (Woo et al., 2012), and received significant attention after an outbreak in Ohio, United States in 2014 (Wang et al., 2014; Shan et al., 2024). Interestingly, a previous study reported that the PDCoV (CHN/AH-2004) strain was isolated from Anhui Province, China, as early as 2004 (Dong et al., 2015). PDCoV has spread rapidly throughout the United States, China, South Korea, Japan, Thailand, and Vietnam, posing an enormous threat and economic loss to the commercial pork industry (Zhao et al., 2019; Kong et al., 2022). See also; https://en.wikipedia.org/wiki/Porcine_epidemic_diarrhea_virus or https://en.wikipedia.org/wiki/Porcine_epidemic_diarrhea_virus ; A Bayesian study of 138 genomes showed that the virus has six subtypes.[5] Groups 1 and 2 originated in North America and groups 3–5 originated in Asia. The evolution rate of the genome was estimated to be 3.38 × 10−4 substitutions/site/year similar to other RNA viruses. The most recent common ancestor of the extant strains evolved ~1943. - PED is transmitted by fecal-oral transmission and the infectious dose is low. Pre-weaned piglets shed large amounts of virus in their feces resulting in rapid spread and high mortality rates. Older animals do not shed as much virus in their feces as piglets. It can also be spread via contaminated fomites. A study showed that when aerosolized virus particles can spread up to 10 miles from the source of infection. [6] DJ, The TMN story indicates some human organs have receptors that may link up to this pig-covid... A major disaster (earthquake, flooding) does increase the risk of all kinds of animal diseases getting in contact with other hosts.
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