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Cambodia 8th H5N1 case

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Topic: Cambodia 8th H5N1 case
Posted By: Dutch Josh
Subject: Cambodia 8th H5N1 case
Date Posted: 01 Aug 2024 at 9:50pm
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⚠️ BREAKING 🇰🇭 Cambodia Reports 8th Human Case of H5N1 Bird Flu This Year 4-Year-Old Boy in Critical Condition Cambodia's 8th H5N1 bird flu case of 2024: A 4-year-old boy is critically ill after chickens at his home died. Health officials are investigating.
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NEW: Cambodia reports another human case of H5N1 bird flu, the 8th case this year. The patient is a 4-year-old boy who became seriously ill after chickens died at his home.

DJ, different variant of same H5N1 virus...



Replies:
Posted By: Dutch Josh
Date Posted: 01 Aug 2024 at 10:12pm
https://afludiary.blogspot.com/2024/08/cambodia-reports-8th-h5n1-case-of-2024.html - https://afludiary.blogspot.com/2024/08/cambodia-reports-8th-h5n1-case-of-2024.html or https://afludiary.blogspot.com/2024/08/cambodia-reports-8th-h5n1-case-of-2024.html ;

For the third time in the month of July, and the 14th case over the past 18 months, Cambodia's Ministry of Health is reporting a new H5N1 case, this time in a 4 y.o. boy from Svay Rieng Province. 

All of the cases reported in Cambodia to date have been from an older 2.3.2.1c clade of H5N1, which predates the emergence of clade 2.3.4.4b which has spread across much of the rest of the world.

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The boy had a fever, a cough, tiredness, difficulty breathing and drowsiness. At present, the patient's condition has improved and he is receiving intensive care by doctors

According to the interrogation, about 12 days before the onset of illness in the village and at home, the patient had a large number of dead chickens and flowed and brought food to eat, the boy touched and held the dead chickens and liked to play With chicken and duck.

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Of the 14 H5N1 cases reported by Cambodia over the past 18 months, only 3 have been in adults and all of them survived.  Among the 11 children infected - while several had mild symptoms - nearly half (n=5) have died. 


We've seen this affinity of H5N1 to preferentially infect younger people often over the years, although the reasons behind it are poorly understood. 

One possibility we've explored, however, is that your first flu exposure may affect your future response to novel flu viruses (see  https://afludiary.blogspot.com/2016/11/science-protection-against-novel-flu.html - Science: Protection Against Novel Flu Subtypes Via Childhood HA Imprinting ).

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 H5 is an HA Group type 1 while H7 viruses fall in group 2.
  • Those born prior to the mid-1960s were almost certainly first exposed to Group 1 flu viruses (H1N1 or H2N2)
  • Those born after 1968 and before 1977 would have been exposed to Group 2 (H3N2)
  • After 1977, both Group 1 and 2 viruses co-circulated, meaning the first exposure could have been to either one.
This suggests that those born before 1968 may carry some degree of limited protection against H5 infection. 

That said, any advantage of being born in the 1950s or early 1960s is probably being gradually offset by advancing age and comorbidities, and may not be as pronounced today as it was 20 years ago.

Today's report is a reminder that while we are heavily focused on clade 2.3.4.4b of H5N1, there are a number of other novel flu viruses with zoonotic potential that have pandemic potential, and deserve our attention.
DJ, Being exposed to flu types earlier may -for now- offer -limited- protection against new types of flu...

The further in time the more mutations and that means LESS immunity...


Posted By: Dutch Josh
Date Posted: 01 Aug 2024 at 10:26pm
https://flutrackers.com/forum/forum/flutrackers-high-pathogenic-h5n1-h1n08-h5n8-h5n6-h5n3-tracking-outbreaks-spread/749462-flutrackers-2016-global-h5n1-human-cases-list?view=stream - https://flutrackers.com/forum/forum/flutrackers-high-pathogenic-h5n1-h1n08-h5n8-h5n6-h5n3-tracking-outbreaks-spread/749462-flutrackers-2016-global-h5n1-human-cases-list?view=stream or https://flutrackers.com/forum/forum/flutrackers-high-pathogenic-h5n1-h1n08-h5n8-h5n6-h5n3-tracking-outbreaks-spread/749462-flutrackers-2016-global-h5n1-human-cases-list?view=stream latest;

https://flutrackers.com/forum/member/18-sharon-sanders">sharon sanders
https://flutrackers.com/forum/member/18-sharon-sanders - sharon sanders  started a topic  https://flutrackers.com/forum/forum/flutrackers-high-pathogenic-h5n1-h1n08-h5n8-h5n6-h5n3-tracking-outbreaks-spread/749462-flutrackers-2016-global-h5n1-human-cases-list - FluTrackers 2016+ Global H5N1 Human Cases List
FluTrackers 2016+ Global WHO & Ministries of Health Confirmed H5N1 Human Cases List



Please see the 2015 case list  https://flutrackers.com/forum/forum/flutrackers-high-pathogenic-h5n1-h1n08-h5n8-h5n6-h5n3-tracking-outbreaks-spread/720310-flutrackers-2015-global-who-ministries-of-health-confirmed-h5n1-human-cases-list - here .



2024 - (Please note that the US clade is different than the clades in Asia.)


https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/984877-cambodia-reports-7-human-cases-of-bird-flu-h5n1-in-2024-july-8th-2024?p=994625#post994625 - Cambodia  - Male, 4, onset July 18, good condition, contact with dead chickens, Svay Rieng Province

https://flutrackers.com/forum/forum/welcome-to-the-scientific-library/other-scientific-studies-including-seasonal-novel-flu/h5n1-research-studies-papers-academia/994601-medrxiv-a-one-health-investigation-into-h5n1-avian-influenza-virus-epizootics-on-two-dairy-farms - United States  - 2 dairy farm workers in Texas in April 2024, research paper (low titers, cases not confirmed by US CDC yet)

https://flutrackers.com/forum/forum/united-states/h5n1-tracking-af/colorado/993492-colorado-state-health-officials-confirm-7-cases-of-avian-flu-in-colorado-poultry-workers-july-12 - United States  - 9 human cases in Colorado​ - poultry farmworkers - situation developing...​

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/984877-cambodia-reports-7-human-cases-of-bird-flu-h5n1-in-2024-july-8th-2024?p=993228#post993228 - Cambodia  - Female, 5, relative and housemate of male, 3, below - announced July 8

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/984877-cambodia-reports-6-human-cases-of-bird-flu-h5n1-in-2024-july-5th-2024?p=993203#post993203 - Cambodia  - Male, 3, contact with dead chicken, under treatment - test positive July 5

https://flutrackers.com/forum/forum/united-states/h5n1-tracking-af/colorado/993086-colorado-dairy-worker-tests-positive-for-bird-flu-becoming-fourth-case-tied-to-dairy-cattle-in-the-us - United States  - Dairy cow farmworker, mild case with conjunctivitis, recovered, Colorado - reported July 3

https://flutrackers.com/forum/forum/united-states/h5n1-tracking-af/michigan/991326-us-third-farm-worker-infected-2nd-case-in-michigan-may-30-2024 - United States  - Dairy cow farmworker, from a separate farm, in contact with H5 infected cows, Michigan - reported May 30, 2024

https://flutrackers.com/forum/forum/united-states/h5n1-tracking-af/michigan/990923-michigan-human-cases-of-h5n1-2024-1-case - United States  - Dairy cow farmworker in contact with H5 infected livestock, Michigan - reported May 22, 2024

https://flutrackers.com/forum/forum/oceania/h5n1-tracking-ai/australia/990878-australia-government-statement-human-case-of-h5n1-avian-influenza-detected-in-returned-traveller-to-victoria-from-india-may-22-2024 - Australia  - A child who traveled from India in March 2024 - reported May 22, 2024

https://flutrackers.com/forum/forum/united-states/h5n1-tracking-af/987593-us-several-samples-taken-from-dairy-cows-test-positive-for-highly-pathogenic-avian-influenza-in-texas-kansas-idaho-michigan-potentially-new-mexico-march-24-one-texas-human-case-april1?p=988026#post988026 - United States  - Dairy cow farmworker in Texas, details pending - reported April 1

https://flutrackers.com/forum/forum/asia/h5n1-h5n8-h1n08-tracking/vietnam-aa/987502-vietnam-khanh-hoa-media-student-with-h5n1-avian-flu-infection-has-reportedly-died-possible-infection-from-poultry-or-wild-birds-mentioned-march-22#post987570 - Vietnam  - Male, 21, onset March 11, hospitalized March 16, died, March 23, student, Khanh Hoa province Death

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/984877-cambodia-reports-1st-human-case-of-bird-flu-h5n1-in-2024-january-26-2024#post984877 - Cambodia  - Male, 3, hospitalized in ICU, Prey Veng province

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/984877-cambodia-reports-2-human-cases-of-bird-flu-h5n1-in-2024-january-26-2024?p=984959#post984959 - Cambodia  - Male, 69, Siem Reap province, hospitalized in ICU

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/984877-cambodia-reports-3-human-cases-of-bird-flu-h5n1-in-2024-january-26-2024 - Cambodia  - Male, 9, died, Kratié province Death

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/984877-cambodia-reports-4-human-cases-of-bird-flu-h5n1-in-2024-january-26-2024#post985616 - Cambodia  - Male, 16, brother of case above, Kratié province

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/984877-cambodia-reports-5-human-cases-of-bird-flu-h5n1-in-2024-january-26-2024?p=986001#post986001 - Cambodia  - Female, 17, stable condition, Kampot province.


2023

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/982164-cambodia-ministry-of-health-announces-h5n1-bird-flu-in-a-21-year-old-woman-in-kampot-province-november-24-2023%E2%80%8B#post982244 - Cambodia  - Female, 4, onset November 23, neighbor of the case below, hospitalized in ICU on November 24, Kampot province

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/982164-cambodia-ministry-of-health-announces-h5n1-bird-flu-in-a-21-year-old-woman-in-kampot-province-november-24-2023%E2%80%8B - Cambodia  - Female, 21, onset November 19, hospitalized in ICU on November 23, died November 26, Kampot province Death

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/980223-cambodia-moh-confirms-and-a-media-report-of-a-new-h5n1-avian-flu-human-death-october-8-2023 - Cambodia ​ - Female, 2, Prey Veng province, Death

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/980223-cambodia-moh-confirms-and-a-media-report-of-a-new-h5n1-avian-flu-human-death-october-8-2023 - Cambodia  - Male, 50, Svay Vieng province, Death

https://flutrackers.com/forum/forum/europe/h5n1-tracking/united-kingdom-and-northern-ireland/976696-uk-ukhsa-2-human-h5n1-avian-flu-cases-asymptomatic-july-14-2023 - UK  - UKHSA: 2 human H5N1 avian flu cases (asymptomatic) - July 14, 2023

https://flutrackers.com/forum/forum/europe/h5n1-tracking/united-kingdom-and-northern-ireland/974229-uk-health-security-press-release-h5-avian-flu-detected-in-2-individuals-taking-part-in-testing-programme-may-16-2023 - UK  - UKHSA has detected influenza A (H5) virus in 2 poultry workers​ - details pending - May 16, 2023

https://flutrackers.com/forum/forum/south-america/h5n1-tracking-ab/chile/971903-chile-ministry-of-health-reports-the-1st-case-of-h5n1-bird-flu-in-a-human-march-29-2023 - Chile  - Male, 53, onset March 13, hospitalized March 22 to ICU

https://flutrackers.com/forum/forum/china-h5n1-h5n8-h5n6-h5n3-h5n2-h10n8-outbreak-tracking/969557-china-media-report-that-who-reported-a-human-case-of-h5n1-bird-flu-confirmed-by-who-march-2-2023 - China  - Female, 53, onset January 31, hospitalized in Jiangsu province February 4, history of poultry contact, Anhui province

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/968975-cambodia-death-of-11-yr-old-female-in-prey-veng-province-h5n1#post968992 - Cambodia  - Female, 11, onset February 16, hospitalized about February 19, died February 22 Death

https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/968975-cambodia-death-of-11-yr-old-female-in-prey-veng-province-h5n1#post968992 - Cambodia  - Male, father of case above, apparently mild case, found with contact tracing




2022

https://flutrackers.com/forum/forum/south-america/h5n1-tracking-ab/ecuador-aa/966807-ecuador-moh-confirms-human-infection-with-hpai-h5-january-10-2023 - Ecuador  - Female, 9, onset December 25, hospitalized December 30, contact with poultry

https://flutrackers.com/forum/forum/united-states/h5n1-tracking-af/colorado/947222-us-colorado-government-press-release-state-health-officials-investigate-a-detection-of-h5-influenza-virus-in-a-human-in-colorado-exposure-to-infected-poultry-cited-april-28-2022-cdc-statement-confirmed-h5n1 - US  - European strain - Male, 40, poultry worker, test confirmed on April, 27, mild case. Colorado state

https://flutrackers.com/forum/forum/europe/h5n1-tracking/spain/959907-spain-avian-influenza-h5n1-detected-in-a-worker-at-a-poultry-farm-in-guadalajara#post960015 - Spain  - European strain - Male, 19, poultry worker, test confirmed September 27, mild case, Guadalajara province*

https://flutrackers.com/forum/forum/europe/h5n1-tracking/spain/962055-who-avian-influenza-a-h5n1-spain-3-november-2022-2-h5n1-cases-in-poultry-workers - Spain  - European strain - Male, 27, poultry worked who initially tested negative, tested positive on October 13, mild case, Guadalajara province*

https://flutrackers.com/forum/forum/china-h5n1-h5n8-h5n6-h5n3-h5n2-h10n8-outbreak-tracking/963825-china-chp-closely-monitors-human-case-of-avian-influenza-a-h5n1-in-mainland-38-yr-old-female-in-qinzhou-guangxi-died - China  - Female, 38, poultry exposure, onset September 22, hospitalized September 25, died October 18, Qinzhou, Guangxi province Death

https://flutrackers.com/forum/forum/asia/h5n1-h5n8-h1n08-tracking/vietnam-aa/961089-vietnam-government-report-vietnam-records-first-human-case-of-bird-flu-in-8-years-5-yr-old-female-in-phu-tho-province-a-h5-type-october-21-2022?p=961203#post961203 - Vietnam  - Female, 5, hospitalized October 8, recovered, Phu, Tho



2021


https://flutrackers.com/forum/forum/india/india-emerging-diseases-and-other-health-threats/919872-india-reports-this-year-s-first-bird-flu-death-h5n1-aiims-delhi-staff-placed-under-isolation - India  - Male, 11, hospitalized July 2, died in New Delhi, from Haryana state. Death

https://flutrackers.com/forum/forum/europe/h5n1-tracking/united-kingdom-and-northern-ireland/934254-uk-government-confirms-an-avian-flu-type-h5-human-case-january-6-2022 - UK  - European strain - Male, 79, kept ducks in house, onset late December 2021, confirmed January 6, 2022, mild case. South West, England


2020


https://flutrackers.com/forum/forum/asia/h5n1-h5n8-h1n08-tracking/laos/898253-laos-human-case-of-h5n1-influenza-reported-who-november-2020 - Laos  - Female, 1, onset October 13, Sarawan province


2019


https://flutrackers.com/forum/forum/china-h5n1-h5n8-h5n6-h5n3-h5n2-h10n8-outbreak-tracking/812033-nepal-possible-h5n1-avian-flu-death-reported-after-recent-outbreaks-in-ducks-chickens-crows-may-2-2019 - Nepal  - Male, 21, onset and hospitalized March 24, died March 29, test positive at WHO lab in Japan on April 30, Kavrepalanchok district. Death



2018

https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/800086-egypt-media-report-moh-has-screened-1600-suspected-human-bird-flu-cases-so-far-in-2018-with-no-confirmed-results-september-29-2018 - Egypt - Media report: MoH has screened 1600 suspected human bird flu cases so far in 2018 with no confirmed results - September 29, 2018



2017

1)  https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/771634-%E2%80%8Begypt-first-2017-death-from-h5n1-bird-flu-fayoum-governorate-february-25-2017-possible-family-cluster - Egypt  - Male, 48, onset February 10, hospitalized February 15, died February 24, reportedly a worker on duck farm, Fayoum Death WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_03_16_2017.pdf - link

2)  https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/771678-egypt-fao-reports-h5n1-avian-flu-case-in-minya-governorate-february-27-2017 - Egypt  - Male, 4, onset February 2, hospitalized February 10, discharged February 20, Minya WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_03_16_2017.pdf - link

3)  https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/776313-egypt-fao-reports-a-human-case-of-h5n1-bird-flu-in-cairo-dated-may-8-2017 - Egypt  - Male, 35, onset April 6, hospitalized April 16, discharged April 23, FAO report of a WHO notification, Cairo WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_05_16_2017.pdf - link

4)  https://flutrackers.com/forum/forum/indonesia/indonesia-tracking-h5n1-outbreaks/bali/783171-indonesia-fatal-human-case-of-influenza-a-h5n1-was-reported-from-bali-province-sept-2017-who - Indonesia  - One case mentioned in media and WHO report



2016

1)  https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/748961-egypt-fao-confirmed-human-case-of-h5n1-avian-influenza-in-sohag-governorate-march-8-2016 - Egypt  - Female, 2, onset February 25, recovered, Sohag WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_04_04_2016.pdf - link

2)  https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/749567-egypt-fao-reports-a-human-case-of-h5n1-bird-flu-in-cairo-march-10-2016 - Egypt  - Female, 7, onset March 4, recovered, Cairo WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_04_04_2016.pdf - link

3) https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/749592-egypt-fao-reports-a-human-case-of-h5n1-bird-flu-in-giza-march-12-2016 -  Egypt  - Female, 5, onset February 24, recovered, Giza WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_04_04_2016.pdf - link

4)  https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/749592-egypt-fao-reports-a-human-case-of-h5n1-bird-flu-in-giza-march-12-2016 - Egypt  - Female, 70, onset March 8, critical, Giza WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_04_04_2016.pdf - link  Death  http://empres-i.fao.org/empres-i/2/obd?idOutbreak=211363&rss=t - note

5)  https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/753441-egypt-ministry-of-health-case-of-bird-flu-infection-in-dakahlia - Egypt  - Male, 50, onset May 2, died May 16, Dakahlia WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_06_13_2016.pdf - link  Death  http://empres-i.fao.org/empres-i/2/obd?idOutbreak=212293&rss=t - note

6)  https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/757578-egypt-who-announces-3-new-human-h5n1-bird-flu-cases-july-19-2016 - Egypt  - Male, 2, onset May 30, sample collected via routine testing, Cairo WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_07_19_2016.pdf?ua=1 - link

7)  https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/757578-egypt-who-announces-3-new-human-h5n1-bird-flu-cases-july-19-2016 - Egypt  - Female, 30, onset June 11, hospitalized & recovered, Minya WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_07_19_2016.pdf?ua=1 - link

8)  https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/757578-egypt-who-announces-3-new-human-h5n1-bird-flu-cases-july-19-2016 - Egypt  - Female, 8, onset June 88, hospitalized & recovered, Cairo WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_07_19_2016.pdf?ua=1 - link

9) Egypt - Male, 3, onset May 7, died May 20, healthy poultry exposure, Fayoum WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_10_03_2016.pdf - link  Death

10) Egypt - Female, 3, onset July 24, died July 31, market poultry exposure, Giza WHO  http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_10_03_2016.pdf - link  Death


-------------------------------------------------
Notes

Please see:

* These cases are refuted as of 2/23/2023. Please see:  https://flutrackers.com/forum/forum/welcome-to-the-scientific-library/other-scientific-studies-including-seasonal-novel-flu/h5n1-research-studies-papers-academia/969080-eurosurv-influenza-a-h5n1-detection-in-two-asymptomatic-poultry-farm-workers-in-spain-september-to-october-2022-suspected-environmental-contamination - Eurosurv. Influenza A(H5N1) detection in two asymptomatic poultry farm workers in Spain, September to October 2022: suspected environmental contamination

https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/783113-egypt-moh-representative-declares-bird-flu-is-not-a-threat-10-h5n1-cases-in-2017-september-25-2017 - Egypt - MoH representative declares bird flu is not a threat, 10 H5N1 cases in 2017? - September 25, 2017

https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/775234-egypt-fao-issued-45-h5n1-event-reports-for-march-2017-25-reports-do-not-have-a-description-of-an-animal - Egypt - FAO issued 45 H5N1 event reports for March 2017: 25 reports do not have a description of an animal


Not confirmed by WHO:

https://flutrackers.com/forum/forum/egypt/h5n1-tracking-egypt/756343-egypt-media-report-man-27-tested-positive-and-hospitalized-with-bird-flu-in-qena-h5n1-july-2-2016 - Egypt - Media report: Man, 27, tested positive and hospitalized with bird flu in Qena - H5N1? - July 2, 2016


Please note these 2 cases are reported for year 2015 and appear on that list linked above:

China - Male, 42, critical condition, Chengdu, Sichuan  http://www.chp.gov.hk/files/pdf/2016_avian_influenza_report_vol12_wk16.pdf - note

Bangladesh - Male, 60, recovered, Mymensing, Bangladesh  http://www.chp.gov.hk/files/pdf/2016_avian_influenza_report_vol12_wk16.pdf - note
Last edited by  https://flutrackers.com/forum/member/18-sharon-sanders - sharon sanders ; Yesterday, 06:04 PM.

DJ, Age matters more than gender in outcome...the younger the higher chance of not surviving H5N1. Are there cases of H5N1 in children missing/misdiagnosed ? 



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