Post Reply - Corona/CoViD-news

Coronaviridae

Kashif Pirzada, MD
@KashPrime
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Good deep dive into the recent paper by Nguyen et al about why we don't develop long-term antibody immunity to Covid from the mRNA vaccines (and from infection).

Turns out the spike proteins in the virus are spaced in just such a way that antibodies can't crosslink and trigger the formation of long lived plasma cells in the bone marrow.

There's hope that Novavax and future vaccines might overcome this, but will need more study. Bone marrow sampling is exceedingly painful and it's hard to get volunteers...
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Harry Spoelstra
@HarrySpoelstra
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Oct 16
“The bad news is the failure of SARS2 mRNA vaccines themselves—with or without natural infections—to induce long-lived plasma cells (LLPCs) in the bone marrow/protective immunity." 
 Excellent commentary article on last months LLPC's study findings. https://science.org/content/article/missing-immune-cells-may-explain-why-covid-19-vaccine-protection-quickly-wanes
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https://x.com/KashPrime/status/1846710437124985092/photo/1 or https://x.com/KashPrime/status/1846710437124985092/photo/1 
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https://x.com/KashPrime/status/1846710437124985092/photo/2 or https://x.com/KashPrime/status/1846710437124985092/photo/2 

DJ, Corona-virus infections are NOT new ! In farming they were a known risk for over 90 years...https://en.wikipedia.org/wiki/Coronavirus_diseases or https://en.wikipedia.org/wiki/Coronavirus_diseases ;
Coronavirus diseases are caused by viruses in the coronavirus subfamily, a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, the group of viruses cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the common cold (which is also caused by other viruses, predominantly rhinoviruses),^[1]^[2] while more lethal varieties can cause SARS, MERS and COVID-19.^[3]^[4] As of 2021, 45 species are registered as coronaviruses,^[5] whilst 11 diseases have been identified, as listed below.
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The first coronavirus disease was discovered in the late 1920s. Coronaviridae were generally of limited interest to the wider scientific community, until the appearance of SARS. Human coronaviruses were discovered in the 1960s, through a variety of experiments in the United States and the United Kingdom.^[12] A common origin in human coronaviruses is bats.^[13]

DJ, Untill SARS-1 showed up in 2003 corona-virusses were seen as "very limited risk" for humans...Since there are MILLIONS of possible health risks we were not ready for SARS-1...still managed to contain it....by taking enough action. From testing to stop travel...

The "bad news" for SARS-2/CoViD-19 is bad choices were made then-still are made now...

DJ-History repeats itself because people do not want to learn from it, face it....In many countries even today "history" is used for "nation-building", propaganda...NOT for learning from previous mistakes...