Post Reply - CoViD in the 1980's ????

Tatiana Prowell, MD
@tmprowell
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Researchers exposed skeletal muscle to serum from ppl w/ #MECFS or #LongCovid

@48
 hrs : contractile
profile severely compromised, shift to glycolysis 

@ 96-144 hrs: high fatiguability, fragile tissue, fragmented mitochondria

#MedTwitter, PEM is real.  

link; https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353  or https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353 ;
Prolonging the exposure to 96 and 144 hours induced high fatiguability, and fragility in tissues.

 The mitochondria, at longer exposures, appeared to be fragmented and assumed a toroidal conformation indicating a change in mitochondrial membrane potential. 

We hypothesize that the disease progresses through an intermediary stress-induced hypermetabolic state, ultimately leading to severe deterioration of muscle function. 

This is the first account of research that proposes acquired metabolic plasticity in 3D skeletal muscles exposed to ME/CFS and Long COVID-19 sera.

-DJ-The conclusion -my view- pushing people with ME-CFS/Long CoViD beyond their limits brings serious damage...
Tatiana Prowell, MD
@tmprowell
·
Oct 9
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To be clear for anyone new to my posts, this study isn’t when I decided post-exertional malaise (PEM) is real. Many people w/ #MECFS & #LongCovid have described severe fatigue & said exertion worsens symptoms, sometimes dramatically. Listen to patients. Believe them. #MedTwitter

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