Post Reply - Corona/CoViD-news

   DJ-Possibly very welcome good news;
https://www.thailandmedical.news/news/new-breakthrough-in-covid-19-treatment-involving-a-dual-inhibitor-blocking-virus-entry or https://www.thailandmedical.news/news/new-breakthrough-in-covid-19-treatment-involving-a-dual-inhibitor-blocking-virus-entry -link to;

https://link.springer.com/article/10.1038/s12276-024-01283-2 or https://link.springer.com/article/10.1038/s12276-024-01283-2 ;

 In this study, we identified UNI418, a dual PIKfyve and PIP5K1C inhibitor, as a new chemical agent that inhibits SARS-CoV-2 entry into host cells.
-
We also demonstrated that UNI418 prevented ACE2-mediated endocytosis of the virus via PIP5K1C inhibition.

DJ-So CoViD would not get into the cells/host..."UNI418" preventing that !

MAH
@Med58ll
·
45m
< aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;">
Nieuwe studie suggereert dat het in India goedgekeurde en gebruikte Covid-19 neusvaccin, de overdracht blokkeert in het experimentele model. (DJ-New India study suggesting a nose vaccine blocking the CoViD virus in hamsters). 

https://www.science.org/doi/10.1126/sciadv.adp1290 or https://www.science.org/doi/10.1126/sciadv.adp1290 ;

Here, we evaluated the impact of mucosal or intramuscular vaccine immunization on airborne infection and transmission of SARS-CoV-2 in Syrian hamsters. Immunization of the primary contact hamsters with a mucosal chimpanzee adenoviral-vectored vaccine (ChAd-CoV-2-S), but not intramuscular messenger RNA (mRNA) vaccine, reduced infectious virus titers ~100-fold and 100,000-fold in the upper and lower respiratory tract of the primary contact hamster following SARS-CoV-2 exposure.

 This reduction in virus titer in the mucosal immunized contact animals was sufficient to eliminate subsequent transmission to vaccinated and unvaccinated hamsters. In contrast, sequential transmission occurred after systemic immunization with the mRNA vaccine. Thus, immunization with a mucosal COVID-19 vaccine protects against cycles of respiratory transmission of SARS-CoV-2 and can potentially limit the community spread of the virus.

https://www.thailandmedical.news/news/sars-cov-2-kp-variants-seems-to-be-evolving-towards-causing-chronic-infections-kp-3-3-with-orf1a-i1367l-debuts-in-europe or https://www.thailandmedical.news/news/sars-cov-2-kp-variants-seems-to-be-evolving-towards-causing-chronic-infections-kp-3-3-with-orf1a-i1367l-debuts-in-europe -link;

https://github.com/sars-cov-2-variants/lineage-proposals/issues/1801 or https://github.com/sars-cov-2-variants/lineage-proposals/issues/1801 ;

I keep a large list of such sequences, and after adjusting for mutation frequency in circulating lineages, ORF1a:I1367L is the 19th most frequent chronic-infection mutation (considering only mutations that appear at least 10 times independently). Restricting to sequences that appear at least 20 times independently, it comes in at #8.

But as described above, it's a mutation that has been virtually nonexistent in circulating lineages, which is why it's remarkable that it has succeeded so well in KP.3.3 over the last two months, primarily in Europe, but also with detections in five of the six other inhabited continents.

DJ, A mutation in CoViD19 resulting in (even) more chronic infections...With most CoViD infections ignored-both in humans and other mammal hosts...

CoViD undermines immunity-so lots of other diseases will see MORE spread...H5N1, Mpox etc. 

-"politicians for sale" going for more wars-creating trillions of debts PER YEAR !!!! are a danger for human existence...

CoronaHeadsUp
@CoronaHeadsUp
< aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;">
Paris Olympics: National Olympic Committee urges athletes to be 'aware of COVID-19'. 

DJ, The France Olympics may be the worst CoViD spread event since the  https://en.wikipedia.org/wiki/2019_Military_World_Games or https://en.wikipedia.org/wiki/2019_Military_World_Games (october 18-27-2019 Wuhan China). 

CoViD 19 was detected in several places around the globe before october 2019...