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Topic - H5N1/flu (other types)
Posted: 16 Jul 2024 at 10:18pm By Dutch Josh
Pixie-thanks for a good link;

https://www.cidrap.umn.edu/avian-influenza-bird-flu/officials-probe-heat-wave-factors-h5n1-spread-colorado-poultry-cullers or https://www.cidrap.umn.edu/avian-influenza-bird-flu/officials-probe-heat-wave-factors-h5n1-spread-colorado-poultry-cullers ;

As the investigation continues into recent avian flu infections in as many as five workers who culled Colorado poultry, officials today said that industrial fans in poultry barns where temperatures exceeded 104°F could have spread the virus through windblown feathers and through the air, potentially reducing the effectiveness of personal protective equipment (PPE).

Also, early genetic analysis suggests that the virus that infected the poultry and the workers is the same H5N1 genotype infecting dairy cattle, a useful clue for officials who are examining connections between the farms.


DJ, mutations;
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H5N1. CLOSER and CLOSER ! The new mutation in avian influenza viruses PB2-627V allowing the virus to efficiently infect both birds and humans, https://biorxiv.org/content/10.1101/2024.07.03.601996v2

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#H5N1 #AvianFlu updates Quick Analysis of the sequence of H5N1 (clade 2.3.4.4b) #Colorado human case uploaded to PB2 mutations: T58A, V109I, V139I, E249G, E362G, K389R, D441N, V478I, V495I, M631L*, V649I, M676A * Dairy cattle outbreak signature
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Sequence uploaded from Colorado contains unique PB2 E249G & NS1 R21Q mentioned in Singh et al. Detection and characterization of H5N1 HPAIV in environmental samples from a dairy farm. Virus Genes (2024) https://link.springer.com/article/10.1007/s11262-024-02085-4
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DJ the above mutations are those different in farm workers from poultry/cattle (I think). At least 12-with 2 extra in one case ???

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