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| Mpox Discussion Forum: Latest News & Information Regarding the Clade 1b Mpox Virus |
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| Topic - A new pandemic Posted: 11 Mar 2025 at 12:30am By Dutch Josh 2 |
 < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Differnet outcomes b/w bovine H5N1, and human case of bovine H5N1. Human virus = enhanced polymerase activity vs bovine, in human cells. PB2 mutation E627K is major contributor. PB2 E362G, K627E affect morbidity, mortality, and viral replication.
 https://biorxiv.org/content/10.1101/2025.03.01.640810v1.abstract- https://timesofindia.indiatimes.com/city/patna/bird-flu-30-human-samples-to-be-sent-for-testing-no-need-to-panic-says-civil-surgeon/articleshow/118819468.cms or https://timesofindia.indiatimes.com/city/patna/bird-flu-30-human-samples-to-be-sent-for-testing-no-need-to-panic-says-civil-surgeon/articleshow/118819468.cms ;  < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> India: 30 human bird flu samples sent for testing
"No need to panic", says civil surgeon.
The Times of India DJ, After poultry outbreak in India also farmworkers are now beeing tested...  < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> DJ, what part of H5N1 is already "mixed up" in "normal flu"? How much is CoViD spreading in combination with Flu-is there any testing on CoViD...Could it be CoViD is escaping testing in (severe) flu cases ????
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