Post Reply - A new pandemic

Frontiers in Cellular and Infection Microbiology

   DJ, Warmer sea water is stronger storms...Some diseases may be spread as dust-from dried up bird droppings-may explain "unclear infection stories"....
https://flutrackers.com/forum/forum/local-regional-communities-and-organizations/cidrap/1000875-cidrap-climate-change-may-drive-migratory-birds-farther-north-introducing-exotic-tick-borne-diseases or https://flutrackers.com/forum/forum/local-regional-communities-and-organizations/cidrap/1000875-cidrap-climate-change-may-drive-migratory-birds-farther-north-introducing-exotic-tick-borne-diseases ;

Climate Change Rising temperatures fueled by climate change may allow pathogen-infected ticks attached to birds migrating from tropical to cooler locations to survive at their destinations, researchers reported this week in Frontiers in Cellular and Infection Microbiology.
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Mapping the distributions of tick-carrying bird species during spring migrations highlighted geographic hot spots where songbirds could shed pathogen-carrying ticks on the way to or upon arrival at their breeding grounds, the latter showing average dispersal distances of 421 to 5,003 kilometers (262 to 3,109 miles). Short-distance migrants carried more ticks than their long-distance counterparts.

DJ, Birds going into "new" areas may bring lots of diseases into those areas/animals...new to the region. 

https://www.thailandmedical.news/news/columbia-study-warns-that-covid-19-kp-3-1-1-and-xec-variants-are-highly-immune-evasive-than-even-jn-1-or-kp-3  or https://www.thailandmedical.news/news/columbia-study-warns-that-covid-19-kp-3-1-1-and-xec-variants-are-highly-immune-evasive-than-even-jn-1-or-kp-3 link to;
https://www.biorxiv.org/content/10.1101/2024.11.17.624037v1 or https://www.biorxiv.org/content/10.1101/2024.11.17.624037v1 ;

KP.3.1.1 is currently the most prevalent subvariant worldwide, while the recombinant subvariant XEC is exhibiting the fastest growth rate.
 Here we measured the in vitro neutralization of KP.3.1.1 and XEC by human sera, monoclonal antibodies, and soluble hACE2 receptor relative to their parental subvariants KP.3 and JN.1. KP.3.1.1 and XEC were slightly more resistant (1.3-1.6-fold) than KP.3 to serum neutralization, and the resultant antigenic map showed that the new subvariants are antigenically similar.

 Both also demonstrated greater resistance to neutralization by select monoclonal antibodies and soluble hACE2, all of which target the top of the viral spike.
 Our findings suggested that upward motion of the receptor-binding domain in spike is partially hindered by the N-terminal-domain mutations found KP.3.1.1 and XEC, thereby allowing these subvariants to better evade serum antibodies that target the viral spike when it is in the up position and thus having a growth advantage in the population.

DJ, New variants of CoViD also interact with older variants/immunity...New variants of CoViD that "work better" with other widespread diseases-like types of flu- may have more chance of spreading. 

‪Henry Niman PhD‬ ‪@hlniman.bsky.social‬
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5h
Cullers in BC infecting poultry?

DJ, animal-human-animal spread ? 

Also, one reason why "Europe" may have low/no H5N1 human cases is "limited testing in higher risk groups"...(but PPE may be more in use, also higher level of vaccination compared with most of the US ???)...so very likely there may be less/no cases yet...

However with increase of wild bird spread of H5-flu types Europe may see an increase of human H5-infections (H5N5 ???)

DJ-my non-expert view; the "main new pandemic" is decrease of immunity after coViD resulting in more room for other diseases like Mpox, H5/H7 types of flu etc. 

A "testing period" of what diseases mix best-in what hosts-may be the present "pre-crisis". We "may not know what hit us" when a mix of diseases establishes itself...

As always-hope to be very wrong !