Post Reply - H5N1/flu (other types)

really know

Rick Bright
@RickABright
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This mutation in NA of human #H5N1 is well known to assoc w/ drug resistance to oseltamivir. It should be a clear trigger to immediately diversify SNS holdings. Fewer than 1M doses of baloxavir held, w/ 12+ mo lead to make more. 

Did mutation appear pre or post oseltamivir treatment? Is this NA mutation also in #H5N1 from pigs & from human case in Canada? Glad baloxavir & IV antivirals were available for Canada, timing is a factor on their effectiveness. 

Urgently need to  surveillance,  SNS drug diversity,  data for combo therapy, &  data sharing lag

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Raj Rajnarayanan
@RajlabN
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#H5N1 #AvianInfluenza Updates  

Quick analysis of the newly uploaded H5N1 sequences from human cases in #Washington   

These sequences contain NA S247N  -- implicated in #antiviral drug resistance/reduced drug sensitivity

DJ, anti-virals save lives...so if H5N1 is developing towards "reduced drug sensitivity" it is bad news...The more types of flu become "anti-viral reduced" the more people will die...

https://afludiary.blogspot.com/2024/11/usda-number-of-confirmed-h5-infected.html or https://afludiary.blogspot.com/2024/11/usda-number-of-confirmed-h5-infected.html ;

With their latest update, the USDA's count of H5 infected herds in the country now sits at 505, across 15 states, with the addition of 13 new herds from California (n=291).  
Of course, with no national mandatory testing of bulk milk or dairy herds, we don't really know how many dairy herds have been affected. 
This `Don't test, don't tell' policy extends beyond just cattle.  Despite sporadic reports of HPAI H5 in goats, in alpacas, and most recently in swine, there appears to be little appetite for testing those herds either.
And state submissions to the USDA's Detection of HPAI in Mammals list have ground to a halt over the past few months, with only 2 samples shown as collected since late July. 

DJ..out of control because lack of will to control it...