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| Mpox Discussion Forum: Latest News & Information Regarding the Clade 1b Mpox Virus |
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| Topic - H5N1/flu (other types) Posted: 07 Nov 2024 at 5:31am By Dutch Josh 2 |
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https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/999915-usda-confirms-2nd-pig-on-oregon-farm-tested-positive-for-h5n1?view=stream or https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/999915-usda-confirms-2nd-pig-on-oregon-farm-tested-positive-for-h5n1?view=stream ;
A week after the first reports of H5N1 being detected in a pig in the United States (see USDA: APHIS Reports 1st Detection of HPAI H5N1 in Swine (Oregon)) the USDA has confirmed that a second pig on the premises has tested positive for the HPAI H5 virus. While this appears to be a limited outbreak on a small, non-commercial farm, this is also the 4th livestock species - joining goats, alpacas, and dairy cattle - to be infected in the United States in the past 7 months. This outbreak - like the large poultry outbreak in neighboring Washington state (with > 1 dozen associated human infections) - comes from the introduction of a new genotype of the virus (D1.1 in Washington State and D1.2 in Oregon) this fall. Since its arrival in late 2021, more than 100 genotypes have been detected in the United States alone. The ability to continually reinvent itself via reassortment makes H5N1 particularly difficult to address, and raises the potential for better adaptation to mammals. - While we've seen scattered reports of H5N1 in swine (see here, here, and here), between extremely limited testing, and the fact that H5N1 tends to be asymptomatic (or mildly symptomatic) in pigs, it is probably more common than we realize. For years we've been warned about the dangers of H5N1 getting into the pig population, since pigs are considered excellent `mixing vessels' for influenza viruses. - Admittedly, none of these spillovers into pigs/cattle/goats has produced a pandemic-capable virus, but with each occurrence there is a small - but non-zero - chance that H5N1 could reassort into a more formidable foe. And as we've seen over the past year, the number of those risky events continues to rise rapidly, which greatly increases the chances of seeing an undesired outcome. DJ...https://flutrackers.com/forum/forum/united-states/h5n1-tracking-af/991361-us-h5n1-human-case-list?view=stream or https://flutrackers.com/forum/forum/united-states/h5n1-tracking-af/991361-us-h5n1-human-case-list?view=stream latest; Late yesterday WA state listed 2 more cases for a total of 14. This brings our list above to 52 known US cases. Please see post #1. Only 2006-Indonesia 55 cases was larger.... https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/999138-two-more-preprints-suggesting-prior-h1n1-infection-may-provide-some-cross-protection-against-%60bovine-hpai-h5n1 or https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/999138-two-more-preprints-suggesting-prior-h1n1-infection-may-provide-some-cross-protection-against-%60bovine-hpai-h5n1 ; But the mystery remains as to why human illness appears to be attenuated with recent H5N1 infections, particularly since the virus remains quite deadly to other mammalian species (cats, mice, foxes, etc.). One intriguing possibility we've seen explored in recent months has been that some (perhaps many) humans have some cross immunity to this H5 virus from past infection (or vaccination against) seasonal H1N1. DJ, Maybe in the latest US/UK H5N1 cases symptoms were mild-SE Asia cases still high CFR-they do not have the same kind of H5N1....maybe different interaction with previous flu-types ?
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