Cor&#111;na/CoViD-news

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Posted: 08 Nov 2024 at 10:43pm

Cat in the Hat

@_CatintheHat

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This is a neat couple of charts from Bob Hawkins where he compares Covid test positivity rates to estimated Covid prevalence across last winter. Right now, test positivity is 6.1%… …so Covid prevalence could be ~2.3%. That’s 1 in 43 people infected.

link;https://bhawkins3.substack.com/p/covid-situation-report-nov-7-2024 or https://bhawkins3.substack.com/p/covid-situation-report-nov-7-2024 ;

This week brings good news with the data showing Covid levels falling across England, Scotland and Wales.

In England, the Covid test positivity rate, hospital admissions and case rates all fell this week, and are at relatively low levels. All regions saw hospital admission rates fall.

In Scotland, Covid levels decreased across all measures, including admissions to hospital, relative to the most recent peak in July.

Over the past week, hospital admissions in Wales have decreased, yet they continue to be moderately high.

Regrettably, the Northern Ireland Surveillance Report for this week has not yet been released, hence no update can be provided.

DJ, https://ourworldindata.org/grapher/excess-mortality-p-scores-average-baseline?time=2023-11-05..latest&country=USA~GBR~NLD or https://ourworldindata.org/grapher/excess-mortality-p-scores-average-baseline?time=2023-11-05..latest&country=USA~GBR~NLD excess deaths still high-with the UK however september 1 excess deaths -1%-so below the long term average !

Still for CoViD statistics on testing/sequencing only show severe, older (in time) cases from hospital...We may also miss "Flu-Rona" cases untill those co-infections show up in hospital/increase of deaths...

DJ-the MSM fake-news-machine is NOT interested in information, only profits...With that a main tool to get a grip on pandemics; information/communication is gone...

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Posted: 10 Nov 2024 at 10:18pm

tern

@1goodtern

10h

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Well it's another study that comes like a kick in the gut. Covid infection in pregnant mothers disrupts immune balance, alters fetal brain cells and increases offspring's risk of neurodevelopmental disorders.

link; https://www.nature.com/articles/s41380-024-02822-z or https://www.nature.com/articles/s41380-024-02822-z ;

Maternal COVID-19 infection increases the incidence of neurodevelopmental disorders (NDDs) in offspring, although the underlying mechanisms have not been elucidated.

This study demonstrated that COVID-19 infection during pregnancy disrupted the balance of maternal and fetal immune environments, driving alterations in astrocytes, endothelial cells, and excitatory neurons.

A risk score was established using 47 unique genes in the single-cell transcriptome of gestational mothers.

The high risk score in CD4 proliferating T cell level served as an indicator for increased risk of offspring NDDs.

Summary-based Mendelian randomization and phenome-wide association study analyses were conducted to identify the causal association of the transcriptional changes with the increased risk of offspring NDDs.

Additionally, 10 drugs were identified as potential therapeutic candidates.

Our findings support a model where the maternal COVID-19 infection changed the levels of CD4 proliferating T cells, leading to the alterations of astrocytes, endothelial cells, and excitatory neurons in offspring, contributing to the increased risk of NDDs in these individuals.

DJ-T-cell damage...

Jane Johnson 〓〓

@JaneJohnsonBakr

10h

Replying to @1goodtern

Or indeed leads to stillbirth, as happened to my poor niece.

DJ, "living with the virus" is getting killed by the virus...on the long run.

https://www.thailandmedical.news/news/how-autoimmune-responses-in-the-brain-could-explain-long-covid-symptoms or https://www.thailandmedical.news/news/how-autoimmune-responses-in-the-brain-could-explain-long-covid-symptoms with a link to;

https://www.sciencedirect.com/science/article/pii/S2090123224005307 or https://www.sciencedirect.com/science/article/pii/S2090123224005307 ;

Conclusions

The current study provides the first evidence indicating that autoimmune responses directed at neuronal proteins play a key role in Long COVID disease. Brain reactive autoantibodies directed at MBP, MOG, tubulin, CP2, and synapsin are elevated in patients with Long COVID disease indicating a neuro-autoimmune pathophysiology of this condition. The severity of the physio-affective phenome (CFS, depressive and anxiety dimensions), which represents a major dimension of Long COVID, is significantly predicted by increased IgM/IgA-synapsin, IgA/IgG-MBP, IgG-MOG, and CRP and AOPP levels. The current study is a proof of concept and mechanism study that autoimmune, inflammatory, and oxidative responses play a significant role in the pathophysiology of Long COVID disease, and in the CFS and affective symptoms (the physio-affective phenome) due to Long COVID.

Our findings highlight the pivotal role of immune-inflammatory responses in LC and align with evidence-based psychiatry's focus on integrating biological markers for guiding diagnosis and treatment [78]. By addressing the fundamental pathways that connect immunological dysregulation to psychiatric disorders, such integration enhances clinical practice.

DJ, Disease often is the result of immunity system fighting an infection....Sometimes the virus/bacteria NEEDS a strong immune reaction. However over-reaction/ immunity going on after the disease is gone or damage by the immune reaction itself can be a problem.

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and https://www.thailandmedical.news/news/china-identifies-new-feline-coronavirus-that-is-extremely-lethal-and-could-pose-a-threat-to-humans or

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Posted: 16 Nov 2024 at 5:50am

https://www.thailandmedical.news/news/scientists-warn-a-new-sars-cov-2-lineage-that-will-have-more-mutations-and-pose-challenges-will-likely-emerge-early-2025 or https://www.thailandmedical.news/news/scientists-warn-a-new-sars-cov-2-lineage-that-will-have-more-mutations-and-pose-challenges-will-likely-emerge-early-2025

with link to;

https://www.preprints.org/manuscript/202411.0947/v1 or https://www.preprints.org/manuscript/202411.0947/v1

https://www.thailandmedical.news/news/china-identifies-new-feline-coronavirus-that-is-extremely-lethal-and-could-pose-a-threat-to-humans

link tohttps://onlinelibrary.wiley.com/doi/10.1155/2024/4162458 or https://onlinelibrary.wiley.com/doi/10.1155/2024/4162458

DJ-my non-expert view; biggest risks

-non human spread of CoViD goes on...

-lack of testing/sequencing=missing developments

Resulting in CoViD come-back with variants for wich we have no protection...mixing with lots of other diseases...The "new pandemic" is loss of immunity...may be one of the reasons why the US is now seeing that much human H5N1 cases...

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Posted: 10 hours 36 minutes ago at 4:22am

Ryan Hisner

@LongDesertTrain

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Do you remember BA.3—the weakling cousin of BA.1 & BA.2 that seemed to take the worst from each & had weaker ACE2 binding than even the ancestral Wuhan Virus? After 3 years, BA.3 is back. And it is transmitting. Who saw this coming?

While the full extent of the new BA.3’s spread is not known, it’s been detected in 2 different South African regions through regular (not targeted) surveillance by

@Dikeled61970012

@Tuliodna

, & the invaluable South African virology community.

After nearly 3 years of intrahost evolution in a chronically infected person, the new BA.3 is almost unrecognizable. It has ~41 spike AA substitutions (4 of which are 2-nuc muts) to go with 14 AA deletions (∆136-147+∆243-244). We’ve seen nothing like this since 2023.

The new BA.3 has added 3-4 new glycans in spike at: N101 (via I101T), N185 (K187T), N354 (K356T—in 1/3 sequences), & N529 (K529N). Plus it lacks T19I, so it retains the N17 glycan that we’ve not seen since BA.1 (& which Delta also lacked due to T19R).

Like BA.2.87.1, the new BA.3 has rearranged its spike NTD (S:1-325) by eliminating the C15-C136 disulfide bond with P9L (which shunts C15 into the signal peptide, which gets cleaved off) & ∆136-147, which eliminates S:C136.

New BA.3 is also looking quite trim and fit these days! Like several late-XBB variants, it has shorn itself of ORF7ab & ORF8 with a deletion of over 800 nucleotides. It appears to be the same deletion that GW.5.1.1 (an XBB) had.

As always, there’s a lot to unpack with this new saltation variant. For now, I’ll just briefly mention one fascinating mutation, and save more extensive analysis for later. The new BA.3 has one of my favorite rare, enigmatic mutations: S:A852K.

S:A852K is a 2-nucleotide mutation that’s appeared almost exclusively in highly divergent chronic-infection sequences. The last sequence to have A852K was a Cryptic-like BA.1 from New York in mid-2023 w/striking similarities to the new BA.3, including...

...NTD disulfide erasure through P9L + ∆C136, N164K, a new N185 glycan via K187T, the H505Y reversion, H681R, and of course A852K. Fortunately, the new BA.3 does not have the notorious ORF3a:H182D, which seems to kill a disturbing proportion of the people it infects.

I don’t know what A852K does. K854 used to bond with D614 before D614G became universal, & A852K has appeared with K854N several times. The BA.3 has many mutations in that region, so maybe it affects up/down spike conformation. https://science.org/doi/10.1126/science.abf2303…

Will the new BA.3 spread across the world & grow? There’s no way to know. It may sputter & die like BA.2.87.1. But BA.2.87.1 arrived just when JN.1 was sweeping the world & was trampled underfoot. The ground is now more fertile, & a novel-variant seed more likely to bloom.

It’s been a year and a half since we’ve seen a truly novel variant spread & just saw the weakest winter Covid wave ever. I suspect JN.1 variants have become weaker over time, forced into acquiring infectivity-reducing spike mutations to evade broadening antibodies.

If the new BA.3 circulates long enough to pick up some transmission-enhancing mutations (think BA.2.86 getting L455S to become JN.1), it could be the next big thing. Or not. Time will tell. We should see it in other countries pretty soon if it’s the real deal.

DJ...

So this BA.3 (now designated BA.3.2) had not reappeared since I posted this thread... until today, when a BA.3.2 showed up in the Netherlands—the first detection outside of South Africa. April 2 collection date. BA.3 ain't dead yet.

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