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Mpox Discussion Forum: Latest News & Information Regarding the Clade 1b Mpox Virus

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Dutch Josh 2 View Drop Down
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Points: 1150 		Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 17 Jan 2025 at 5:54am
DJ-Mpox becoming a global problem since 2022 -in my view-very likely to be linked to CoViD decreasing immunity...(this goes also for lots of other diseases...)

https://flutrackers.com/forum/forum/africa-ac/monkeypox/994145-burundi-mpox-monkeypox-outbreak-2024-2025?view=stream or https://flutrackers.com/forum/forum/africa-ac/monkeypox/994145-burundi-mpox-monkeypox-outbreak-2024-2025?view=stream ;
Burundi: Mpox invades 93% of health districts

January 15, 2025

Monkeypox (MPox) continues its alarming progression in Burundi, now affecting 93% of the country's health districts. According to the latest UNICEF report published on January 12, 2025, the situation has worsened considerably compared to the previous year, with a rapid and widespread spread of the disease.

As of January 5, 2025, UNICEF specifies in its report, 46 of Burundi's 49 health districts have reported cases of Mpox, compared to only 33 the previous year. Out of 3,355 people screened, 1,767 tested positive, revealing the scale of the epidemic. Children are particularly vulnerable, representing 37% of positive cases among those under 15, making them the most affected age group.

Bujumbura province remains the epicenter of the epidemic, with its health districts being the hardest hit.

In the same report, UNICEF stresses that it is committed to continuing its support to the Burundian government, particularly by providing the kits needed to fight the epidemic.
-
13 January 2025
...
Burundi Mpox Level 3 Emergency

HIGHLIGHTS

As of January 05, 2025, the epidemic has spread from 46 health
districts out of 49, or 93.8% of the districts. Of these, 17 are currently
active, having reported at least one confirmed case in the last 21 days
compared to 26 in November and 33 in October.

A total of 1,767 cases out of 3,035 confirmed cases reported were
recorded in three health districts of Bujumbura (Bujumbura North,
Center and South), or 58,2%. Bujumbura North continues to be the
most affected district with 1,142 cases, or 37.6% compared to 38.1% in
November.

Children under 15 years of age remain the most affected group with
37.8% compared to 39.5% in November; children under 5 years of age
represent 20.6% of total confirmed cases, compared to 21.7% in
November. However, young adults between 20 and 30 years of age
now represent 30,7% of cases, compared to 29.7% in November.
6,924 people affected by Mpox, including 3,557 children (51,3%), have
benefited from psychosocial support and mental health services in the
treatment centers and in the community.

DJ, There have been some claims of aerosol spread of Mpox in schools...

Lack of testing, reporting, sequencing only increase risks of both further spread and new clades/variants...
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Points: 1150 		Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 19 Jan 2025 at 11:35am
https://flutrackers.com/forum/forum/africa-ac/monkeypox/1003943-drc-mpox-monkeypox-outbreak-2025?view=stream or https://flutrackers.com/forum/forum/africa-ac/monkeypox/1003943-drc-mpox-monkeypox-outbreak-2025?view=stream (latests)

A case of Mpox confirmed in a displaced persons site in Oicha

Published on Tue, 01/14/2025 - 04:57 PM | Modified on Tue, 01/14/2025 - 04:57 PM

A first confirmed case of Mpox has been reported in the rural health zone of Oicha, in the territory of Beni (North Kivu). It is a two-month-old infant, who lives with his mother in the Luvangira displaced persons site.

According to medical sources, the case was suspected on January 5, when samples were taken for analysis. These confirmed that the child had monkeypox. Two other suspected cases were also reported in the same displaced persons site.

Archipe Kule Kyusa, the supervising nurse in charge of preventive activities and epidemiological surveillance, indicates that all measures have been taken to follow up on contacts at risk and thus avoid the spread of the disease.

"The health zone has just reported a positive case of Monkey pox. It is a two-month-old child and curiously his family lives in a displaced persons site.Our fear is that the case is where people are crowded together, there is a risk that the spread of the disease will be great ," fears the nurse.

This is why the health zone and the ECZ team thought it better to list the contacts. In the meantime, there were two other people who presented the same signs and are already at the Monkey Pox Treatment Center (CTM) in Oicha, he adds.

According to Archipe Kule Kyusa, the medical staff is sensitizing the local population to prevent this disease by washing their hands regularly. He is also recommending vaccination, especially for families where these cases are found.
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Mpox: the situation in the Democratic Republic of Congo remains “worrying” (WHO)

January 13, 2025 Health

Although most trends appear "stable," the monkeypox situation in the Democratic Republic of the Congo (DRC) remains "worrying," the UN health agency (WHO) said on Monday, noting that the outbreak of the Mpox virus clade Ib continues mainly in the country, Burundi and Uganda, but also new travel-related cases have been identified in some countries that were not previously affected.

According to the World Health Organization ( WHO ), the DRC remains the most affected country, with circulation of both subclades I of Mpox. Generally speaking, the epidemic curves of suspected smallpox cases in the 12 most affected provinces show that these provinces have varying epidemic sizes, but for most of them, the trend over the last few weeks appears relatively stable.

In provinces where MPXV clade Ia and clade Ib are known to co-circulate, including the capital Kinshasa, the trend of suspected cases has also been relatively stable over the past few months.

However, even though "most trends appear stable, the situation in the country remains worrying, as it shows a high and continued circulation of the virus," the WHO detailed in its latest epidemiological report.

More than 9,500 cases in the DRC including 43 deaths

Since its first detection in September 2023, clade Ib has been detected in eight provinces of the DRC: South Kivu, North Kivu, Kinshasa, Kasai, Tshopo, Tanganyika, Haut-Katanga and Mai Ndonbe.

In Africa, from January 2024 to January 5, 2025, 14,700 confirmed cases of Mpox, including 66 deaths, were reported by 20 countries. The most affected country remains the Democratic Republic of Congo (9,513 cases including 43 deaths). This is followed by Burundi (3,035 confirmed cases, including one death) and Uganda (1,552 confirmed cases, including 12 deaths).

Burundi and Uganda continue to report between 100 and 200 new smallpox cases per week, with a tendency to plateau, possibly due to a drop in surveillance and reporting during the December holiday period.

Community transmission has also been reported in other countries on the continent, such as Kenya and Rwanda. Travel-related cases have been reported in Zambia and Zimbabwe. In addition, although no cases have been confirmed to date in Tanzania, the identification of travel-related smallpox cases in Tanzania suggests undetected transmission in that country.

Mpox cases in Europe and North America linked to travel to Africa

Outside Africa, eleven countries have detected MPXV clade Ib. Sweden, Thailand, the United States of America and Canada have detected one case each among travellers from affected countries in East and Central Africa.

For WHO, these recent travel-associated smallpox cases highlight the risk of undetected transmission within countries, underscoring the need for enhanced surveillance and timely reporting to improve global monitoring and prevent international spread.

A travel-related case of Mpox due to clade Ib in Germany (the second importation) led to secondary transmission at home. Germany has thus confirmed six cases: three cases among travellers from affected countries in East Africa and three household contacts of one of these travellers.

MPXV clade Ib has been detected in three other countries, Belgium, China and France, directly or indirectly linked to travel to the affected countries in Central Africa.

Kosovo reported its first case of MPXV. No information on the MPXV clade is yet available.

DJ, In "official numbers" CoViD in Africa was "limited"...but it has to be translated to "we did not test because we did not care"...So Mpox better able to spread may be an outcome...
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https://news.sky.com/story/new-case-of-mpox-detected-in-england-13293030 or https://news.sky.com/story/new-case-of-mpox-detected-in-england-13293030 ;

New case of Clade Ib mpox detected in England

It is the sixth case of the variant confirmed in England since October 2024 but officials say the latest infection has no links to the previous cases and the risk to the UK population "remains low".
-

It was detected in East Sussex and the individual is now under the specialist care of Guy's and St Thomas' NHS Foundation Trust.

The patient had recently returned from Uganda, where there is currently community transmission of Clade Ib mpox, also known as monkeypox.
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Points: 1150 		Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: Yesterday at 12:09am
https://flutrackers.com/forum/forum/welcome-to-the-scientific-library/poxviridae-including-monkeypox/1005223-in-a-%E2%80%98shocker%E2%80%99-decision-japan-approves-mpox-drug-that-failed-in-two-efficacy-trials-science-aaas or https://flutrackers.com/forum/forum/welcome-to-the-scientific-library/poxviridae-including-monkeypox/1005223-in-a-%E2%80%98shocker%E2%80%99-decision-japan-approves-mpox-drug-that-failed-in-two-efficacy-trials-science-aaas ;

In a ‘shocker’ decision, Japan approves mpox drug that failed in two efficacy trials - Science AAAS

17 JAN 2025. 6:50 PM ET​
BY JON COHEN​

doi: 10.1126/science.zs6ktjw

On 2 January, Japan’s regulatory agency issued a news release that startled some scientists: It had approved the antiviral drug tecovirimat, also known as TPOXX, for the treatment of mpox and two cousins, smallpox and cowpox.

No treatments exist for mpox, a painful and sometimes fatal disease now raging in sub-Saharan Africa, and tecovirimat initially looked promising: It prevented death in monkeys given lethal doses of mpox and smallpox virus. The European Unionand the United Kingdom both approved it in 2022, after an earlier epidemic of mpox in men who have sex with men (MSM). At the time, the drug had been shown to be safe in humans, but no efficacy data existed. ...

link; https://www.science.org/content/article/shocker-decision-japan-approves-mpox-drug-failed-two-efficacy-trials or https://www.science.org/content/article/shocker-decision-japan-approves-mpox-drug-failed-two-efficacy-trials ;

But in the past 6 months, two such studies have definitively shown tecovirimat doesn’t work in people infected with either of the two clades of mpox virus. “To approve it now is very confusing,” says Jason Zucker, an infectious disease specialist at Columbia University who co-led one of the trials, the Study of Tecovirimat for Human Mpox (STOMP), which enrolled mostly MSM in the United States, Japan, Latin America, South Africa, and Thailand. “I am very curious to read studies used by Japanese [regulators] to approve it,” adds epidemiologist Placide Mbala of the Democratic Republic of the Congo’s (DRC’s) National Institute of Biomedical Research, who helped run the other trial, named PALM007. That study, in the DRC, tested the drug in children as well as adults and also found no benefit.

DJ, Money/profits ?
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Points: 1150 		Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh 2 Quote  Post ReplyReply Direct Link To This Post Posted: 4 hours 25 minutes ago at 12:36am
https://flutrackers.com/forum/forum/national-international-government-ngo-preparation-response/cdc-guidance-on-monkeypox/1005373-mpox-in-the-united-states-and-around-the-world-current-situation-january-16-2025  or https://flutrackers.com/forum/forum/national-international-government-ngo-preparation-response/cdc-guidance-on-monkeypox/1005373-mpox-in-the-united-states-and-around-the-world-current-situation-january-16-2025 ;

Mpox in the United States and Around the World: Current Situation - January 16, 2025

January 16, 2025

Mpox in the United States and Around the World: Current Situation

What to know
  • There are two types of the virus that causes mpox, clade I and clade II. Both types spread the same way and can be prevented using the same methods.
  • There have been cases or outbreaks of clade I mpox in several countries in Central and Eastern Africa.
  • There have also been several travel-associated clade I mpox cases reported in countries in other parts of Africa, Europe, Asia, and North America.
  • CDC is working with public health partners in the United States and throughout Africa to monitor for mpox cases and increase surveillance capacity, in addition to other activities.
  • Clade II mpox cases continue to spread at low levels in many countries around the world.

Current situation

In the United States
  • The first case of clade I mpox in the United States was confirmed in California in November 2024 following the patient's travel to an affected area. The patient has recovered, and no additional cases were reported.
  • The second case of clade I mpox in the United States was confirmed in Georgia on January 14, 2025, in a traveler from a country experiencing sustained mpox transmission. The patient is in isolation and is recovering, and no additional cases have been reported.
  • CDC assessed the risk to the United States overall population and specific populations within the United States posed by the clade I mpox outbreak as low.
  • Clade II mpox is still circulating at low levels.
  • Children have historically gotten mpox in endemic areas in Western and Central Africa, and in this outbreak the high number of children with mpox reported in likely reflects spread within households. Based on what we know right now, we don't expect to see the same sort of risk in children if mpox were introduced in the United States for reasons including different household makeup and size, access to disinfecting products, and improved access to medical care.
Clade I Mpox Outbreak Originating in Central Africa
Ongoing Clade II Mpox Global Outbreak


Across the globe
  • There are outbreaks of clade I mpox in Central and Eastern Africa.
    • Clade I has two subclades, clade Ia and clade Ib.
    • In Central Africa, people have gotten clade Ia mpox through contact with infected dead or live wild animals, household transmission, or patient care; a high proportion of cases have been reported in children younger than 15 years of age.
    • Subclade Ib was recently identified in eastern DRC and has been spread through intimate and adult sexual contact between different demographics, including heterosexual spread with sex trade workers. So far, clade Ib has a lower case-fatality rate than clade Ia mpox.
  • Sustained and local person-to-person spread of clade I mpox has taken place in some non-endemic countries through sexual contact, day-to-day household contact, and within the healthcare setting in the absence of personal protective equipment.
  • he countries of Burundi, Democratic Republic of the Congo, Kenya, Rwanda, and Uganda are experiencing sustained human-to-human transmission of the virus; there is also evidence of sustained transmission in Central African Republic (CAR) and Republic of the Congo (ROC).
  • Countries reporting travel-associated cases of clade I mpox include Belgium, Canada, China, France, Germany, India, Oman, Pakistan, Sweden, Thailand, the United Kingdom, the United States, Zambia, and Zimbabwe.
  • The ongoing global outbreak of clade II mpox has caused more than 100,000 cases in 122 total countries, including 115 countries where mpox was not previously reported. The outbreak is caused by the subclade IIb.
  • Historically, only Cameroon in West Africa had cases of both clade I and clade II mpox, as both clades are endemic, but in different parts of the country.
Global mpox cases: data dashboard and mapData as of: 16-Jan-25

DJ, the trump-show may stop testing/reporting..."so there are no reported new Mpox cases in the US" ...The real pandemic is insanity !
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