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H5N1/flu (other types) |
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Dutch Josh 
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Joined: 23 Jun 2024 Status: Offline Points: 554 |
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 Topic: H5N1/flu (other types)Posted: 01 Jul 2024 at 12:29am |
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DJ, CoViD very likely killing hundreds of people worldwide each day...Mpox -for now- most a problem in Africa...
H5N1 however is "global" -both in birds and mammals... In the US H5N1 keeps spreading in cows and cats...Due to lack of testing (and symptoms ?) so far human H5N1 cases -in the US- seems limited... One of the reasons why H5N1 keeps spreading in the US is trade in infected cows is still ongoing... "Poultry litter" to feed cows is NOT stopped...In the US cows ear bird "droppings"...birds eat cow "droppings"...so H5N1 may be "pumped around".... A level of insanity I can not comprehend...The US Department of Agriculture (USDA) is NOT stopping H5N1 spread in the US... We live in the age of insanity !
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Pixie
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Posted: 01 Jul 2024 at 2:24am |
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The US supreme court has overturned Chevron,now any agency’s regulations or guidance (cdc,usda) can be challenged in court and negated by a judge.Say a mechanic of an airline says three bolts instead the standard five would hold an engine on a wing it, they can challenge that in court and and possibly win. With this country so divided, this can wreak havoc in all of American life. . |
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Dutch Josh
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Posted: 01 Jul 2024 at 2:33am |
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Hi Pixie,
Implications of legal/ "political" fight on pandemic (response) indeed looks terrible... One way of looking at it-cynical- is "ignoring the risks" may "deal with those that ignore the risk"... Michael Olesen     @maolesen · So H5 is showing up in wastewater in CA. Is it from cows or people? San Francisco and Palo Alto don't strike me as cattle country. -  < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> H5N1 bird flu virus detected at 3 Bay Area wastewater sites in the past 2 weeks: SF x 2, Richmond, Palo Alto. CA appears to be the only state reporting H5N1 in wastewater that has yet to report H5N1 infected cattle. "Urban origin" is concerning. May be from wild poultry markets. DJ-the "good news" is the US at least has some level of H5N1 testing...Most countries may do even less...Mexico does import (infected ?) cattle from the US...has a higher consumption of "raw milk"... "no testing = no cases" has its limits...
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Pixie
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Posted: 01 Jul 2024 at 2:44am |
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They have found it in waste water around milk processing plants and pork processing plants.Both release thousands of gallons of water into the system,nowhere near an infected dairy farm. Running out the door now,I’ll link later.
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Dutch Josh
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Posted: 04 Jul 2024 at 2:02am |
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Feeding raw milk-products to pigs may be spreading H5N1 into pigs...https://www.farmanddairy.com/columns/feeding-weaning-pigs-waste-milk-lowers-feed-costs-improves-efficiency/254040.html or https://www.farmanddairy.com/columns/feeding-weaning-pigs-waste-milk-lowers-feed-costs-improves-efficiency/254040.html ;
The Northeast region of the United States has more than 15,000 working dairies, each producing non-saleable waste milk. Waste milk contains excess colostrum, transition milk, mastitic milk, or antibiotics. Many dairy producers feed waste milk to dairy calves, however, sometimes the amount of waste milk is in excess of what can be used resulting in it being disposed. Feeding waste milk to other species provides a viable option for dairy producers to use the product rather than waste it. Option for pigsFor a pig, weaning is thought to be the most stressful time of its life, as it transitions from a completely liquid diet to a completely dry diet. Waste milk may serve to ease this transition to dry feed while keeping the pig hydrated. DJ, If no one is stopping this practice it may continue...H5N1 in pigs may mix with other types of flu... https://www.thailandmedical.news/news/colorado-reports-male-infected-with-h5n1-from-dairy-cattle-fourth-case-in-united-states-more-cases-expected or https://www.thailandmedical.news/news/colorado-reports-male-infected-with-h5n1-from-dairy-cattle-fourth-case-in-united-states-more-cases-expected ... There are less than 2 million H5-flu tests available in the US...unclear who decides who gets tested and who will pay for that testing...  < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> - https://cdphe.colorado.gov/press-release/colorado-state-health-officials-identify-a-human-case-of-avian-flu or https://cdphe.colorado.gov/press-release/colorado-state-health-officials-identify-a-human-case-of-avian-flu ; The adult male had mild symptoms, reporting only conjunctivitis (pink eye). He reported his symptoms to state health officials, who tested him for influenza at the State Public Health Laboratory. Specimens forwarded to CDC for additional testing were positive for avian flu. CDPHE gave the individual antiviral treatment with oseltamivir in accordance with CDC guidance. He has recovered. This case is an employee at a dairy farm in northeast Colorado who had direct exposure to dairy cattle infected with avian flu. To protect patient privacy, additional details are not being provided. DJ...they are NOT protecting privacy but they are hiding a timeline...
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Dutch Josh
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Posted: 06 Jul 2024 at 11:52pm |
 < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Three key issues with #H5N1
1) mild disease means likely under detection. Severe disease shows up to hospitals; mild not so much
2) ongoing spillovers mean continuous chance for mutations/ human adaptation
3) human flu season gets closer by the day; human or animal w/ co-infection means risk of viral reassortment —> higher pandemic risk DJ https://flutrackers.com/forum/forum/flutrackers-high-pathogenic-h5n1-h1n08-h5n8-h5n6-h5n3-tracking-outbreaks-spread/749462-flutrackers-2016-global-h5n1-human-cases-list?view=stream or https://flutrackers.com/forum/forum/flutrackers-high-pathogenic-h5n1-h1n08-h5n8-h5n6-h5n3-tracking-outbreaks-spread/749462-flutrackers-2016-global-h5n1-human-cases-list?view=stream latest; In 2024 different H5N1 clades in humans; -Cambodia 6 human cases -US had 4 -Australia 1 Vietnam 1 So the first half-more or less-of 2024 did see 12 H5N1 human cases in 4 countries... In 2023-all of it !- we had 10 human cases; -Cambodia 6 -UK 2 -China 1 -Chile 1 Since H5N1 OFTEN !!!! is mild it may be very easy to miss ! The Case Fatality Ratio is not very realistic...The "killing potential" however may be very serious ! It is the background that matters ! H1N1-"Spanish Flu" had World War One -chaos-as a background...CoViD-immunity destruction-may give H5N1 (mixed with lots of other diseases and "politics gone stupid") all the room it needs ! |
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Dutch Josh
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Posted: 09 Jul 2024 at 7:34am |
 < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> link to https://www.khmertimeskh.com/501519079/two-takeo-boys-confirmed-infected-by-h5n1-bird-flu/ or https://www.khmertimeskh.com/501519079/two-takeo-boys-confirmed-infected-by-h5n1-bird-flu/ (May refer to case 6 & 7 this year from Cambodia...). https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/984877-cambodia-reports-7-human-cases-of-bird-flu-h5n1-in-2024-july-8th-2024?view=stream or https://flutrackers.com/forum/forum/cambodia/cambodia-h5n1-tracking/984877-cambodia-reports-7-human-cases-of-bird-flu-h5n1-in-2024-july-8th-2024?view=stream latest; Cambodia detects another H5N1 bird flu case in human ... July 8, 2024 at 06:45:15 ... The Cambodian Ministry of Health on July 8 announced that another human case of H5N1 bird flu has been confirmed on a 5-year-old girl in Takeo province, bringing the number of the infections to seven since the start of 2024. According to the ministry, the patient has a fever and is the cousin of a 3-year-old boy, who tested positive for the virus on July 5. The two children live in the same house in Kiri Vong district's Pou village. ... Among the seven human cases of H5N1 bird flu so far this year were six children, one of whom died, and an adult. All patients reportedly had a history of recent exposure to sick or dead poultry prior to their illness. ... From 2003 to date, there were 69 cases of human infection with H5N1 influenza, including 42 deaths in the Southeast Asian country, according to the ministry./. DJ, https://flutrackers.com/forum/forum/national-international-government-ngo-preparation-response/eu-statements-european-centre-of-diseases-control-and-prevention-ecdc-updates-statements-news/993242-ecdc-avian-flu-increased-vigilance-recommended-july-8-2024 or https://flutrackers.com/forum/forum/national-international-government-ngo-preparation-response/eu-statements-european-centre-of-diseases-control-and-prevention-ecdc-updates-statements-news/993242-ecdc-avian-flu-increased-vigilance-recommended-july-8-2024 ; News 8 Jul 2024 Avian influenza viruses continue to circulate, albeit at low levels, among wild bird populations across the European Union and the European Economic Area (EU/EEA). In the United States, transmission of highly pathogenic avian influenza HPAI A(H5N1) viruses has recently been observed in dairy cattle and four cases of human avian influenza have been reported among farm workers exposed to cattle since April 2024. Whilst transmission from infected animals to humans remains a rare event, avian influenza viruses can spill over to wild, farm and domestic animals, leading to infection and outbreaks in poultry, and occasionally in mammals. “As we closely monitor the current situation on avian influenza, both in the EU and globally, there is reason for increased awareness but not for increased concern. ECDC remains committed in our support of the actions taken by national authorities in EU Member States. This threat to human health should not be underestimated, and it is important that we stay alert and proactive in our joint collaboration.” says Pamela Rendi-Wagner, Director of ECDC. While currently no infection with the avian influenza A(H5N1) virus in humans has been recorded in the EU/EEA, ECDC advises on the importance of continuing to raise awareness among healthcare professionals, both at primary and secondary care level, regarding the possibility of encountering human cases of infection. As part of its ongoing commitment to public health, ECDC is implementing a comprehensive strategy to support the early detection and containment of potential human cases in the EU. simply means the ECDC thinks there could be -possible- limited spread of H5N1 in humans in Europe. (There is no point in "extra vigilance" if they did think 0% of human cases...). https://flutrackers.com/forum/forum/united-states/h5n1-tracking-af/993248-swine-industry-responds-to-h5n1-outbreak-in-dairy-cattle or https://flutrackers.com/forum/forum/united-states/h5n1-tracking-af/993248-swine-industry-responds-to-h5n1-outbreak-in-dairy-cattle ; “The swine industry already has extensive knowledge and experience when it comes to flu management and monitoring. We have multiple programs that can be quickly deployed should H5N1 be detected in swine,” Rotolo observed. Existing programs combined with intentional preparedness efforts equip the pork industry to deploy an effective response to H5N1 in the U.S. swine herd if needed. DJ, A problem could be in H5N1 as a co-infection in swine/pigs...  < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> . article shows dual binding of highly pathogenic avian influenza virus from a dairy cow in the U.S. to both avian- and human-type receptors. This is consistent with the finding of both receptors in cow udders, & raises pandemic risk another notch. link https://www.nature.com/articles/s41586-024-07766-6 or https://www.nature.com/articles/s41586-024-07766-6
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Dutch Josh
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Posted: 09 Jul 2024 at 7:56am |
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https://afludiary.blogspot.com/2024/07/ecdc-call-for-increased-vigilance.html or https://afludiary.blogspot.com/2024/07/ecdc-call-for-increased-vigilance.html ;
Not quite 3 weeks ago the ECDC issued a guidance document (see Enhanced Influenza Surveillance to Detect Avian Influenza Virus Infections in the EU/EEA During the Inter-Seasonal Period) urging member nations to step up surveillance for potential human avian flu infections over the summer. As was reported in last year's analysis from the UKHSA (see TTD (Time to Detect): Revisited), there could be dozens of undetected cases of human H5N1 infection before public health would likely detect them, perhaps even hundreds. While the ECDC may only present non-binding recommendations to member states, yesterday they reiterated the need for increased vigilance in the months ahead. - In recently updated surveillance guidance for the summer period, ECDC recommends lowering the threshold for testing for avian influenza in humans, including using a risk-based approach for exposed asymptomatic individuals. We also recommend testing for influenza all cases hospitalised due to symptoms compatible with avian influenza and to further investigate those influenza A-positive samples that are negative for seasonal influenza virus. Biosafety and personal protective measures in place at occupational and recreational sites with an increased risk of avian influenza remain crucial to minimise the risk of spillover events to humans. These protective measures should be complied with to the greatest extent possible. Furthermore, ECDC has strengthened its support to EU countries on laboratory activities on zoonotic avian influenza, including support on laboratory preparedness to detect and characterise zoonotic influenza viruses. ECDC also offers EU centralised testing and further characterisation for human specimens known or suspected to contain an avian influenza virus. DJ, No doubt possible other types of flu (H5, H7 maybe H9 ???) could be in the back of the ECDC mind...? In addition to being on the alert for avian flu, clinicians are also being asked to have a high index of suspicion for Mpox cases (see COCA Call : Mpox - Clinical Management & Outbreaks), and suspected swine-variant infections.
DJ, And one disease may increase chances (decreasing immunity) for catching another disease...Flu and CoViD both may become harder to detect via testing... I do think there must be cases of "Flu-Rona" Flu and CoVid....maybe testing is missing it ?
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Dutch Josh
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Posted: 10 Jul 2024 at 2:53am |
 < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> It's like H5N1 is throwing out as many red flags as it can, trying its best to warn us. We may be sleepwalking into another pandemic, the consequences of which are unpredictable.
Study paywalled unfortunately. You should be following if you aren't already, BTW. DJ, like with Mpox, CoViD also reporting/testing for H5N1 is the major problem..."bad for tourism"..."saving the economy"... Making the same mistakes all over again ! Maybe the biggest two risks; -Spread of H5N1 we do NOT see (a.o. in mice, rats etc, also wild animals or regions more remote) -Mixing with other (flu)types... Lots of symptoms may be seen in lots of other diseases..so testing positive for one may stop testing for other diseases...The virus feels "more welcome" in hosts with less immunity...
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Dutch Josh
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Posted: 11 Jul 2024 at 10:27pm |
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DJ-A major problem with H5N1 is that it is already very widespread around the globe both in birds and mammals...
 < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> More bad news on #H5N1
#Q591R on PB2 has established itself in a lineage in South Dakota beginning in a May sample. Up to 13 descendants, all from cattle in South Dakota.
Some reading suggests Q591R almost as bad as dreaded E627K:
https://ncbi.nlm.nih.gov/pmc/articles/PMC4249088/…
Seems bad. Experts? https://ncbi.nlm.nih.gov/pmc/articles/PMC4249088/ or https://ncbi.nlm.nih.gov/pmc/articles/PMC4249088/ ; Mutations to PB2 and NP Proteins of an Avian Influenza Virus Combine To Confer Efficient Growth in Primary Human Respiratory CellsOur data show that as few as three mutations, in the PB2 and NP proteins, support robust growth of a low-pathogenic, H1N1 duck isolate in primary human respiratory cells. DJ A 2014 study... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753988/ or https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753988/ ; The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus LineageDJ, H5N1 is moving towards better reproduction in mammals-that is what I (a totally NON-expert !) make of it... We are not doing much to stop H5N1...(flu)vaccines may be of limited use...Masks/eyeprotection do offer protection...but when H5N1 starts spreading from mammal to mammal it may become hard to get people to use them... DJ-Underlying main factor in increase of pandemics is climate collapse..."Politics" kick that can down many roads for decades...Real indications-using 1700-1750 as pre-industrial baseline suggest temperature did increase 2,75C...IPCC still promoting 1,5-2C as a possible limit... https://arctic-news.blogspot.com/2024/07/the-predicament-of-climate-scientists-on-the-road-to-a-super-tropical-earth.html or https://arctic-news.blogspot.com/2024/07/the-predicament-of-climate-scientists-on-the-road-to-a-super-tropical-earth.html Pandemics-including H5N1- are parts of the https://en.wikipedia.org/wiki/Holocene_extinction or https://en.wikipedia.org/wiki/Holocene_extinction
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